Method of increasing viability of stored erythrocytes by additio

Details Method of increasing viability of stored erythrocytes by additio Method of increasing viability of stored erythrocytes by additio

1995-11-08

1998-10-27

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

604 4, A01N 102

Patent

active

058276432

ABSTRACT:
A method of improving the properties of liquid stored or cryogenically stored erythrocytes using D,L-.alpha.-lipoic acid and/or enantiomers or derivatives thereof. Treatment with these substances results in improved oxygen release capacity (2,3-DPG), viscoelasticity and erythrocyte aggregability, and increased resistance to membrane peroxidation during storage and damage by the freeze/thaw process.

REFERENCES:
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Rozanov A et al., Ukr. Biokhim. Zh. 49:45-8 (1977).
Constantinescu A et al, J. Biol. Chem. 268:10906-13 (1993).
Mueller U et al, Evol. Antioxid. Mod. Med. (1994), 57-64 Editors: Schmidt, Diplock and Ulrich.
Hofmann M et al, Arch Biochem Biophys 324:85-92 (1995).

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