Method of increasing the antibiotic yield of producing organisms

Details Method of increasing the antibiotic yield of producing organisms Method of increasing the antibiotic yield of producing organisms

1981-06-18

1983-03-15

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 76, 435172, 435867, 435872, 435886, 435900, 435896, C12P 1962, C12P 1964, C12N 1500, C12R 129, C12R 1365, C12R 1465, C12R 154, C12R 1565

Patent

active

043768237

ABSTRACT:
A method of increasing the yield of a desired product, such as an antibiotic, by an organism which normally must first become inducibly resistant to that product before it can produce the product in maximum yields comprises producing constitutively resistant cells of the organism by supplementing a culture of the organism with an agent in which only cells able to specifically modify the 23S ribosomal RNA constitutively, rather than inducibly, survive thereby producing an organism in which the resistance to the product is expressed without the need for activation by the induction process; followed by purification and utilization of that organism for increased product production.

REFERENCES:
Fujisawa et al., J. Bacteriol., 146(2), 621-631 (May 1981).
Metzler, Biochemistry-The Chemical Reactions of Living Cells, Academic Press, Inc., New York, 908 (1977).
Weisblum et al., J. Bacteriol., 106(3), 835-847 (1971).
Weisblum et al., J. Bacteriol., 137(1), 635-643 (1979).
Graham et al., J. Bacteriol., 137(3), 1464-1467 (1979).
Weisblum et al., J. Bacteriol., 138(3), 990-998 (1979).

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