Method of increasing renal blood flow with dopamine derivatives

Details Method of increasing renal blood flow with dopamine derivatives Method of increasing renal blood flow with dopamine derivatives

1978-03-01

1980-08-26

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424316, A61K 31135

Patent

active

042195683

ABSTRACT:
Certain N,N-dialkyl substituted derivatives of dopamine (DA) increase renal blood flow without affecting cardiac contractility. Particularly effective are N,N-di-n-propyl DA; N-n-propyl-N-n-butyl DA; N-n-propyl-N-n-pentyl DA; N-n-propyl-N-isobutyl DA; and N-n-propyl-N-phenethyl DA. Orally effective versions of these derivatives are obtained by acylating the hydroxyl functions.

REFERENCES:
patent: 4014937 (1977-03-01), Richardson
Volkman et al., Fed. Proc., vol. 36, No. 3, Mar. 1, 1977, Ab. No. 4093, p. 1049.
Ginos et al., Fed. Proc., vol. 37, No. 3, Mar. 1, 1978, Ab. No. 2482, p. 683.

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