Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Reexamination Certificate
2005-06-02
2009-11-17
Ouspenski, Ilia (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
C530S387100
Reexamination Certificate
active
07618627
ABSTRACT:
A method for increasing or monitoring apoptosis in tumor cells by the co-administration of ionizing radiation and an anti-integrin antibody. Increasing apoptosis reduces tumor growth in vivo and in a cell culture model. The antibody is directed against the beta-1 integrin subunit and is inhibitory of beta-1 integrin signaling. Other molecules having an inhibitory effect on beta-1 integrin, either in signaling or in binding to its cognate extracellular receptors may also be used. The present method is particularly of interest in treatment of tumor cells associated with breast cancer, wherein radiation is currently used alone. The present method further contemplates a monoclonal antibody suitable for human administration that may further comprise a radioisotope attached thereto.
REFERENCES:
patent: 5246691 (1993-09-01), Geerlings et al.
patent: 6123941 (2000-09-01), Bissell et al.
patent: 6165467 (2000-12-01), Hagiwara et al.
patent: 6667024 (2003-12-01), Goldenberg et al.
patent: 2006/0035825 (2006-02-01), Wieder
Hallahan et al. Journal of Controlled Release. 2001 74:183-191.
Ole William Petersen, et al., “Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells,”Proc. Natl. Acad. Sci USA, Oct. 1992, vol. 89, 9064-9068.
Yoshikazu Takada, et al., “Identification of a Regulatory Region of lntegrin β1Subunit Using Activating and Inhibiting Antibodies,”J. of Biol. Chemistry, Aug. 1993, vol. 268, No. 23, 17597-17601.
V.M. Weaver, et al., “Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by lntegrin Blocking Antibodies,”J. of Cell Biology, Apr. 1997, vol. 137, No. 1, 231-245.
Lakshmi Chandrasekaran, et al., “Cell Contact-dependent Activation of α3β1 Integrin Modulates Endothelial Cell Responses to Thrombospondin-1 ,”Molecular Biology of the Cell, Sep. 2000, vol. 11, 2885-2900.
Sonali Hemachandra, et al., “Human Monoclonal Antibodies againstPseudomonas aeruginosaLipopolysaccharide Derived from Transgenic Mice Containing Megabase Human Immunoglobulin Loci Are Opsonic and Protective against FatalPseudomonas sepsis,”Infection and Immunity, Sep. 2000, vol. 11, 2885-2900.
D.E. Hallahan, et al., “Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature,”J. of Controlled Release, 2001, vol. 74, 183-191.
Trisha Gura, “Magic bullets hit the target,”Nature, Jun. 2002, vol. 417, 584-586.
Peter J. Hudson, et al., “Engineered antibodies,”Nature Medicine, Jan. 2003, vol. 9, No. 1, 129-134.
Judith S. Ochs, “Rationale and Clinical Basis for Combining Gefitinib (Iressa, ZD1839) with Radiation Therapy for Solid Tumors,”Int. J. Radiation Oncology Biol. Phys., 2004, vol. 58, No. 3, 941-949.
Catherine C. Park, et al., “Ionizing radiation induces heritable disruption of epithelial cell interactions,”PNAS, Sep. 2003, vol. 100, No. 19, 10728-10733.
Gerhard Christofori, “Changing neighbors, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression,”The EMBO Journal, 2003, vol. 22, No. 10, 2318-2323.
ERBITUX™, Package Insert, 2004, Bristol Myers Squibb.
Bissell Mina J.
Park Catherine
Aston David J.
Ouspenski Ilia
Peters Verny LLP
The Regents of the University of California
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