Method of increasing oral absorption of polar bioactive agents

Details Method of increasing oral absorption of polar bioactive agents Method of increasing oral absorption of polar bioactive agents

1982-06-11

1984-07-31

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

424230, 424231, 424232, 424233, 424234, 424235, A61K 3702

Patent

active

044629915

ABSTRACT:
A method and drug form are provided for increasing the oral absorption of polar bioactive agents such as polypeptides by the oral administration of said polar bioactive agents in a suitable pharmaceutically accepted excipient to which has been added a hydroxyaromatic acid or salt as an adjuvant thereof. The adjuvant is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of the polar bioactive agents.

REFERENCES:
Gibaldi, M., et al., J. Pharm. Sci., 62(2), 343-344 (1973).
Imamura, Y., et al., Chem. Pharm. Bull., (Japan), 22, 2324-2328 (1974).
Spector, R., et al., J. Pharm. Exp. Ther., 188(1), 55-65 (1974).
Corell, T., et al., Acta Pharmacol. et Toxicol., 45, 225-231 (1979).
Samejima, M., et al., Yakugaku Zasshi, 88(5), 618-622 (1968).
Sugimoto, I., et al., Yakugaku Zasshi, 88(6), 690-694 (1968).

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