Method of increasing oral absorption of glycosidic and related a

Details Method of increasing oral absorption of glycosidic and related a Method of increasing oral absorption of glycosidic and related a

1982-06-11

1984-07-10

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424230, 424231, 424233, 424234, 424235, 424317, 424335, A61K 3171

Patent

active

044592957

ABSTRACT:
A method and drug form are provided for increasing the oral absorption of glycosidic and related antibiotics such as macrolide, aminoglycoside, lincomycin and anthracycline antibiotics and related chemical species by the oral administration of said glycosidic and related antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxyaryl or hydroxyaralkyl acid or salt thereof. The hydroxyaryl or hydroxyaralkyl acid or salt thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of glycosidic and related antibiotic.

REFERENCES:
Gibaldi, M., et al., J. Pharm. Sci., 62(2), 343-344 (1973).
Imamura, Y., et al., Chem. Pharm. Bull. (Japan), 22, 2324-2328 (1974).
Spector, R., et al., J. Pharm. Exp. Ther., 188(1), 55-65 (1974).
Corell, T., et al. Acta Pharmacol. et Toxicol., 45, 225-231 (1979).
Samejima, M., et al., Yakugaku Zasshi, 88(5), 618-622 (1968).
Sugimoto, I., et al., Yakugaku Zasshi, 88(6), 690-694 (1968).

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