Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1992-10-30
1995-10-17
Furman, Keith C.
Drug, bio-affecting and body treating compositions
Lymphokine
514 12, 514 21, 435212, A61K 3819, A61K 3817, A61K 3804, A61K 3803
Patent
active
054588740
ABSTRACT:
Disclosed is a homogeneously pure monocyte chemotactic protein, CAP37, and the entire coding sequences for unprocessed and mature human CAP37 protein. Further, the recombinant production, from nucleic acid coding sequences, of mature CAP37 protein and the mature protein with amino-terminal and/or carboxy-terminal extensions is described. Also disclosed are methods to identify and recombinantly produce bioactive peptides derived from the CAP37 protein coding sequence which are effective chemoattractants monocytes and/or are capable of binding bacterial lipopolysaccharide. A method of preparing homogeneously pure CAP37 using hydrophobic HPLC is described. Bioactive peptide fragments of CAP37 having chemotactic, antibacterial and/or LPS-binding activity are disclosed. Finally, methods of treating wounds, diseased tissue, such as tumors, and infections are described.
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Pereira Heloise A.
Spitznagel John K.
Emory University
Furman Keith C.
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