Method of increasing efficacy of tumor cell killing using...

Details Method of increasing efficacy of tumor cell killing using... Method of increasing efficacy of tumor cell killing using...

2011-07-12

2011-07-12

Lewis, Patrick (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S042000, C514S049000, C514S045000

Reexamination Certificate

active

07977320

ABSTRACT:
The present invention provides compositions and methods for increasing the amount of active Syk protein kinase and or SHP-1 protein phosphatase in a cell. The compositions and methods are useful for increasing the efficacy of anti-neoplastic agents, such as those that target the CD33 protein, and which are used to treat leukemia. The invention thus provides for treatment of cancers, including leukemias. The invention also provides screening assays for anti-neoplastic agents in vitro. Methods of screening patients for responsiveness to anti-CD33 treatments are also provided.

REFERENCES:
patent: 4671477 (1987-06-01), Cullen
patent: 6007814 (1999-12-01), Scheinberg
patent: 6759045 (2004-07-01), Goldenberg et al.
patent: 2004/0152632 (2004-08-01), Feingold
patent: WO 2004/043461 (2004-05-01), None

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