Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-02-22
2011-10-11
Anderson, James (Department: 1629)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
08034823
ABSTRACT:
The present invention relates generally to the method of increasing the oral bioavailability, reducing chemotherapy induced toxicity and side effects, and improving the effectiveness of pharmaceutical agents that are poorly absorbed from the gastrointestinal tract. Specifically, the invention relates to poorly absorbed pharmaceutical drugs and converting them to orotate salts. The orotate salts of the drugs can be dosed at lower doses to provide the efficacy benefits of a higher dose, while reducing the drugs' toxic effects at lower doses. Additionally, the orotate salts of pharmaceutical agents have better clearance and reduce the potential for drug-induced hepatic toxicity. Therefore, an especially useful formulation of the orotate salt of the pharmaceutical agent can provide rapid and consistent action using a lower dose while reducing drug interactions and side-effects.
REFERENCES:
patent: 3118890 (1964-01-01), Ferguson, Jr.
patent: 3271398 (1966-09-01), Haraoka et al.
patent: 4061741 (1977-12-01), Wawretschek et al.
patent: 5004756 (1991-04-01), Ogawa et al.
patent: 5039527 (1991-08-01), Tabibi et al.
patent: 5461037 (1995-10-01), Cotter
patent: 5710145 (1998-01-01), Engel et al.
patent: 5861406 (1999-01-01), Wehrmann
patent: 5912346 (1999-06-01), Wehrmann
patent: 6184227 (2001-02-01), Karmali
patent: 6239137 (2001-05-01), Karmali et al.
patent: 6258795 (2001-07-01), von Borstel et al.
patent: 6472378 (2002-10-01), von Borstel
patent: 6838090 (2005-01-01), Tabibi et al.
patent: 6858650 (2005-02-01), Meese
patent: 2005/0209247 (2005-09-01), Cai et al.
patent: 645 218 (1964-07-01), None
patent: 2612780 (1977-09-01), None
Malingre et al., Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel, J. Clinical Oncol. vol. 19(4) pp. 1160-1166, 2001.
Merriam-Webster's Collegiate Dictionary, Tenth Edition (1996), Springfiled, Massachusetts, p. 66.
Sobek et al. Arzneimittel-Forschung, 1967, vol. 17, No. 6, pp. 711-714 (Abstract attached).
Gould et al. International Journal of Pharmaceutics, 1986, vol. 33, pp. 201-217.
English Abstract of DE 2612780, STN Accession No. 1978:11920.
Bauer , KS et al, Clin Cancer Res 5:2324-2329 (1999).
Desai et al Cancer Chemother Pharmacol 54: 377-384 (2004).
I. Sugiyama et al ,Biochem Biophy Acta 1653:47-59 (2003).
J. Malingre et al, J Clin Oncol 19: 1160-1166 (2001).
K. Purow et al, Cancer Inv 22: 577-587 (2004).
L. Maccoss et a,l Science 303: 1810-1813 (204).
M. El Hag et al, In Vivo 1: 309-312 (1987).
N. Kohn et al, Cancer Res 52: 3208-3212 (1992).
Bauer et al, J. Pharm Exp Therap 292: 31-37 (2000).
Anderson James
Karmali Rashida A.
Savvipharm Inc
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