Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1998-09-04
2000-12-05
Marschel, Ardin H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
560121, A61K 31557, C07C40500
Patent
active
06156799&
ABSTRACT:
The present invention relates to novel methods of increasing bone volume comprising the administration of a non-naturally-occurring selective FP agonist to a subject in need of such treatment. This invention further relates to a method of treating or preventing bone disorders comprising the administration of a non-naturally-occurring selective FP agonist to a subject in need of such treatment.
REFERENCES:
patent: 4621100 (1986-11-01), Lund et al.
patent: 5310759 (1994-05-01), Bockman
patent: 5409911 (1995-04-01), Tyler et al.
patent: 5703108 (1997-12-01), Cameron et al.
patent: 5747660 (1998-05-01), Orlicky
Griffin et al. FP prostaglandin receptors mediating inositol phosphates generation and calcium mobilization in Swiss 3T3 cells: A pharmacological study. J. Pharmac. And Exper. Therapeut. 281 (2), pp. 845-854, (May 1997).
Woodiel, F.L., Fall, P.M., Raisz, L.G., "Anabolic Effects of Prostaglandins in Cultured Fetal Rat Calvariae: Structure-Activity Relations and Signal Transduction Pathway", Journal of Bone and Mineral Research, vol. 11, No. 9, (1996).
Wada, S., Yasutomo, Y., Kosano, H. Kugai, N., Nagata, N., "The Effect of PGF.sub.2.alpha. On Parathyroid Hormone-Stimulated Cyclic AMP Production in Mouse Osteoblastic Cell, MC3T3E.sub.1 ", Biochimica et Biophysica Acta, vol. 1074, pp. 182-188, (1991).
Collins, D.A., Chambers, T.J., "Effect of Prostaglandins E.sub.1, E.sub.2, F.sub.2.alpha. on Osteoclast Formation in Mouse Bone Marrow Cultures", Journal of Bone and Mineral Research, vol. 6, No. 2, (1991).
Ma, Y.F., Li, X.J., Jee, W.S.S., McOsker, J., Liang, G., Setterberg, R., Chow, S.Y., "Effects of Prostglandin E.sub.2 and F.sub.2.alpha. on the Skeleton of Osteopenic Ovariectomized Rats", Bone, vol. 17, No. 6, pp. 549-554 (Dec. 1995).
Raisz, L.G., Alander, C.B., Fall, P.M., Simmons, H.A., "Effects of Prostaglandin F.sub.2.alpha. on Bone Formation and Resorption in Cultured Neonatal Mouse Calvariae: Role of Prostaglandin E.sub.2 Production", Endocrinology, vol. 126, No. 2 (1990).
Woodward, D.F., Lawrence, R.A., "Identification of a Single (FP) Receptor Associated with Prostanoid-Induced Ca.sup.2+ Signals in Swiss 3T3 Cells", Biochemical Pharmacology, vol. 47, No. 9, pp. 1567-1574, (1994).
Watanabe, T., Nakao, A., Emerling, D., Hashimoto, Y., Tsukamoto, K., Hoie, Y., Kinoshita, M., Kurokawa, K., "Prostaglandin F.sub.2.alpha. Enhances Tyrosine Phosphorylation and DNA Synthesis Through Phospholipase C-coupled Receptor Via Ca.sup.2+ -dependent Intracellular Pathway in NIH-3T3 Cells", The Journal of Biological Chemistry, vol. 269, No. 26, Issue of Jul. 1, pp. 17619-17625, (Jul. 1994).
Ito, S., Sakamoto, K., Mochizuki-Oda, N., Ezashi, T., Miwa, K., Okuda-Ashitaka, E., Shevchenko, V.I., Kiso, Y., Hayaishi, O., "Prostaglandin F.sub.2.alpha. Receptor is Coupled to Gq in cDNA-transfected Chinese Hamster Ovary Cells", Biochemical and Biophysical Research Communications, vol. 200, No. 2, pp. 756-762, (Apr. 1994).
Hakeda, Y., Shiokawa, M., Mano, H., Kameda, T., Raisz, L.G., Kumegawa, T., "Prostaglandin F.sub.2.alpha. Stimulates Tyrosine Phosphorylation and Mitogen-Activated Protein Kinase in Osteoblastic MC3T3-E1 Cells via Protein Kinase C Activation", Endocrinology, vol. 138, No. 5 (May 1997).
Ida, R., Lee, A., Huang, J., Brandi, M.L., Yamaguchi, D.T., "Prostaglandin-Stimulated Second Messenger Signaling in Bone-Derived Endothelial Cells is Dependent on Confluency in Culture", Journal of Cellular Physiology, vol. 160, pp. 585-595, (1994).
Bergmann, P., Schoutens, A., "Prostaglandins and Bone", Bone, vol. 16, No. 4, pp. 485-488, (Apr. 1995).
Yamaguchi, D.T., Green, J., Kleeman, C.R., Muallem, S., "Prostaglandins Enhance Parathyroid Hormone-Evoked Increase in Free Cytosolic Calcium Concentration in Osteoblast-Like Cells", Cell Calcium, vol. 12, pp. 609-622, (1991).
Norrdin, R.W., Jee, W.S.S., High, W.B., "The Role of Prostaglandins in Bone In Vivo", Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 41, pp. 139-149, (1990).
Flanagan, A.M., Chambers, T.J., "Stimulation of Bone Nodule Formation in Vitro by Prostaglandins E.sub.1 and E.sub.2 ", Endocrinology, vol. 130, No. 1 (1992).
Toriyama, K., Morita, I., Murota, S.-i., "The Existence of Distinct Classes of Prostaglandin E.sub.2 Receptors Mediating Adenylate Cyclase and Phospholipase C Pathways in Ostoeblastic Clone MC323-E.sub.1 ", Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 46, pp. 15-20, (1992).
"Lutalyse.RTM.", Veterinary Pharmaceuticals and Biologicals, 8.sup.th Edition, pp. 1066-1069, (1993 & 1994).
Fall, P.M., Breault, D.T., Raisz, L.G., "Inhibition of Collagen Synthesis by Prostaglandins in the Immortalized Rat Osteoblastic Cell Line Py1a: Structure-Activity Relations and Signal Transduction Mechanisms", Journal of Bone and Mineral Research, vol. 9, No. 12, pp. 1935-1943, (1994).
Kawaguchi, H., Pilbeam, C.C., Harrison, J.R., Raisz, L.G., "The Role of Prostaglandins in the Regulation of Bone Metabolism", Clinical Orthopaedics and Related Research, No. 313, pp. 36-46, (1995).
Quarles, L.D., Siddhanti, S.R., "Guanine Nucleotide Binding-Protein Coupled Signaling Pathway Regulation of Osteoblast-Mediated Bone Formation", Journal of Bone and Mineral Research, vol. 11, No. 10, pp. 1375-1383, (1996).
Nemoto, KI., Bernecker, P.M., Pilbeam, C.C., Raisz, L.G., "Expression and Regulation of Prostaglandin F Receptor mRNA in Rodent Osteoblastic Cells", Prostaglandins, vol. 50, pp. 349-358, (Nov. 1995).
Tamura, K., Nemoto, K., Pilbeam, C.C., Raisz, L.G., "Expression and Regulation of Prostaglandin F Receptor mRNA in Rodent Osteoblastic Cells", Abstract T352 (as noted) ASBMR 19.sup.th Annual Meeting, p. S189, No Month or Year Found.
deLong Mitchell Anthony
Hartke James Richard
Lundy Mark Walden
Kellerman James C.
Marschel Ardin H.
McMahon Mary Pat
Moran Marjorie A.
Roof Carl J.
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