Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Reexamination Certificate
2007-11-21
2011-10-11
Naff, David M. (Department: 1657)
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
C424S094400, C424S423000, C424S426000, C424S600000, C435S174000, C435S176000, C435S177000, C435S180000, C435S189000
Reexamination Certificate
active
08034384
ABSTRACT:
A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The reactive agent has nitrite reductase activity, nitrate reductase activity, and/or nitrosothiol reductase activity. The reactive agent also converts at least one of nitrites, nitrates and nitrosothiols to nitric oxide when in contact with blood. A reproducible nitrosothiol sensor is also disclosed.
REFERENCES:
patent: 3933589 (1976-01-01), Keyes
patent: 4339448 (1982-07-01), Dockner et al.
patent: 5169936 (1992-12-01), Staples et al.
patent: 5283339 (1994-02-01), Arnold et al.
patent: 5294539 (1994-03-01), Johannssen et al.
patent: 5386012 (1995-01-01), Strid
patent: 5824673 (1998-10-01), Abrams et al.
patent: 5834030 (1998-11-01), Bolton
patent: 5858792 (1999-01-01), Fanning et al.
patent: 5990289 (1999-11-01), Fauquex et al.
patent: 6033368 (2000-03-01), Gaston, IV et al.
patent: 6143556 (2000-11-01), Trachtenberg
patent: 6284752 (2001-09-01), Abrams et al.
patent: 6569688 (2003-05-01), Sivan et al.
patent: 6645518 (2003-11-01), Tedeschi et al.
patent: 6682732 (2004-01-01), Blake et al.
patent: 6841166 (2005-01-01), Zhang et al.
patent: 7128904 (2006-10-01), Batchelor et al.
patent: 7335383 (2008-02-01), Meyerhoff et al.
patent: 2002/0115559 (2002-08-01), Batchelor et al.
patent: 2004/0224868 (2004-11-01), Meyerhoff et al.
patent: WO 95/04078 (1995-02-01), None
patent: WO 99/09912 (1999-03-01), None
patent: WO 00/02501 (2000-01-01), None
patent: WO 00/11965 (2000-03-01), None
patent: WO 00/12112 (2000-03-01), None
patent: WO 00/27887 (2000-05-01), None
patent: WO 02/056904 (2002-07-01), None
patent: WO 2005/011575 (2005-02-01), None
International Search Report for S.N. PCT/US2004/034613 dated May 18, 2005 (18 pages).
European Search Report for S.N. EP 02 70 75 32 dated Mar. 15, 2005 (5 pages).
Supplemental European Search Report for S.N. EP 02 70 75 32.4 dated Jun. 23, 2005 (8 pages).
Annich, G.M. et al., “Reduced platelet activation and thrombosis in extracorporeal circuits coated with nitric oxide release polymers,” Crit. Care. Med. 2000 v. 28 915-920 (6 pages).
Batchelor, M.M. et al., “More Lipophilic Dialkyldiamine-Based Diazeniumdiolates: Synthesis, Characterization, and Application in Preparing Thromboresistant Nitric Oxide Release Polymeric Coatings,” J Med Chem (2003), 46: pp. 5153-5161.
Batchelor M.M. et al., “Preparation and characterization of nitric oxide releasing polyurethanes for implantable sensor applications,” Sixth World Biomaterials Congress, Kanuela, HI, May 17, 2000, Abstract only (1 page).
Batchelor, M.M. et al., “More biocompatible polyurethanes via nitric oxide release,” Abstracts of Papers of the American Chemical Society 222: 405-POLY Part 2, Aug. 2001, Abstract only, (2 pages).
Batchelor, M.M. et al., “More biocompatible polymers via nitric oxide release,” University of Washington Engineered Biomaterials Conference, Seattle, WA, Aug. 19, 2001 (1 page).
Batchelor, M.M. et al., “Synthesis of nitric oxide-releasing polyurethane,” Proc Am Chem Soc Div PMSE 2001; 84: 594, Abstract only (2 pages).
Batchelor, M.M. et al., “Analytical characterization of novel nitric oxide releasing polymeric films containing diazeniumdiolates,” Pittsburg Conference New Orleans, LA, Abstract 1217, Mar. 16, 2000, Abstract only (1 page).
Cha, W. et al., “Direct Detection of S-Nitrosothiols Using Planar Amperometric Nitric Oxide Sensor Modified with Polymeric Films Containing Catalytic Copper Species,” Anal Chem (2005), 77: pp. 3516-3524.
Cha, W. et al., “S-Nitrosothiol Detection via Ampometric Nitric Oxide Sensor Modified with Polymer film Containing Catalytic Lipophilic Cu(II)-Complex,” The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Orlando, FL (2005), Abstract only, (2 pages).
Chandra, S. et al., “Synthesis and spectral studies on copper (II) complexes of two twelve-membered and tetradentate macrocyclic ligands,” Indian Journal of Chemistry, (Dec. 1998), 37A: pp. 1074-1078.
Doel, J. J. et al., “Reduction of Organic Nitrates to Nitric Oxide Catalyzed by Xanthine Oxidase: Possible Role in Metabolism of Nitrovasodilators,” Biochemical and Biophysical Research Communications., vol. 270, No. 3, pp; 880-885 (Apr. 2000).
Espadas-Torre, C. et al., “Thromboresistant Chemical Sensors Using Combined Nitric Oxide Release/Ion Sensing Polymeric Films,” J Am Chem Soc (1997), 119: pp. 2321-2322.
Fleser, P.S, et al., “Nitric oxide-releasing biopolymers inhibit thrombus formation in a sheep model of arteriovenous bridge grafts,” J Vasc Surg 2004, 40: pp. 803-811.
Frost, M.C. et al., “In Vivo biocompatibility and analytical performance of intravascular Clarke-style amperometric oxygen sensors fabricated with NO-releasing polymers,” Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Orlando, FL, Mar. 13, 2003, Abstract only (1 page).
Frost, M.C. et al., “Improved in vivo biocompatibility and analytical performance of implanted electrochemical oxygen sensors via nitric oxide release,” NAMS, Lexington, KY, May 16 2001, Abstract only (2 pages).
Frost, M.C. et al., “Improved in vivo biocompatibility and analytical performance of implanted electrochemical oxygen sensors via nitric oxide release,” European Society for Biomaterials Meeting, London, England, Sep. 13, 2001, Abstract only (2 pages).
Frost, M.C. et al., “Improved in vivo biocompatibility and analytical performance of implanted electrochemical oxygen sensors via nitric oxide release,” Gordon Research Conference on Bioanalytical Sensors, Ventura, CA Mar. 12, 2002, Abstract only (1 page).
Frost, M.C. et al., “Synthesis and characterization of S-nitrosothiol derivatized fumed silica for use as nitric oxide releasing polymer fillers,” Society for Biomaterials Meeting, Tampa, FL, Apr. 25, 2002, Abstract only (1 page).
Frost, M.C. et al., “Controlled Photoinitiated Release of Nitric Oxide from Polymer Films Containing S-Nitroso-N-acetyl-DL-penicillamine Derivatized Fumed Silica Filler, J Am Chem Soc (2004), 126: pp. 1348-1349.
Frost, M.C. et al., “Improved in Vivo biocompatibility and Analytical Performance of Implanted Electrochemical Oxygen Sensors via Nitric Oxide Release,” Society for Biomaterials Meeting, Reno, NV, May 3, 2003, Abstract only (1 page).
Frost, M.C. et al., “Gore-tex vascular grafts with silicone rubbers capable of releasing nitric oxide for sustained times,” American Society for Artificial Internal Organs, Washington, DC, Jun. 21, 2003, Abstract only (1 page).
Frost, M.C. et al., “Improved in vivo biocompatibility and analytical performance of implanted electrochemical oxygen sensors via nitric oxide release,” Society for Biomaterials Meeting, St. Paul, MN Apr. 27, 2001, Abstract only (1 page).
Frost, M.C. et al., “Synthesis and characterization of S-nitrosothiol derivatized fumed silica used as nitric oxide releasing polymer fillers,” American Chemical Society National Meeting, San Diego, CA Apr. 2, 2001, Abstract 345 only (2 pages).
Frost, M.C. et al., “Analytical characterization of S-nitrosothiol derivatized fumed silica,” Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA Mar. 8, 2001, Abstract only (1 page).
Frost, M.C. et al., “Fabrication and in Vivo Evaluation of Nitric Oxide-Releasing Electrochemical Oxygen-Sensing Catheters,” Meth Enzymol (2004), 381: pp. 704-715.
Frost, M.C. et al., “Implantable chemical sensors for real-time clinical monitoring: progress and challenges,” Curr Opin Chem Biol (2002), 6: pp. 633-641.
Frost, M.C. et al, Polymers incorporating nitric oxide releasing/generating substances for improved biocompatibility of blood-contacting medical devices, Biomaterials (2005), 26
Frost Megan
Hwang Sangyeul
Meyerhoff Mark E.
Reynolds Melissa M.
Wu Yiduo
Dierker & Associates P.C.
Naff David M.
The Regents of The University of Michigan
LandOfFree
Method of increasing biocompatibility of medical device by... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of increasing biocompatibility of medical device by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of increasing biocompatibility of medical device by... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4285845