Method of Increasing activation on proliferation of T cells usin

Details Method of Increasing activation on proliferation of T cells usin Method of Increasing activation on proliferation of T cells usin

1992-11-25

2000-10-10

Venkat, Jyothsan

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424486, 424485, 424450, 4241781, 530866, 530402, 5303911, 53038822, 53038875, 5303896, 5303871, 436536, 436533, 436530, 436529, 436524, 436512, A61K 3940

Patent

active

061299162

ABSTRACT:
Disclosed are conjugates including a polymer backbone or microbead and binding molecules, such as Fv, Fab, or F(ab').sub.2 fragments of monoclonal antibodies or whole antibodies that are bound through their Fc carbohydrate moieties or have their Fc portion modified so that they cannot effect ADCC or complement-mediated cytolysis, and that are specific for a T cell surface antigen, such as CD3, TCR, CD4, CD8, or CD28 on T cells. The polymer or microbead is preferably made of cross-linked dextran, ficoll, latex, or agarose. The microbeads are preferably of 1 to 10 .mu.m in size, so that they can be suspended in in vivo fluids. These conjugates can be used to induce proliferation of T cells and immune stimulation, and to increase the antibody response against an administered antigen.

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Harlow et al Antibodies A Laboratory Manual 1988 Cold Spring Harbor Pours pp. 626-627 & 533.
Charon et al PNAS 78:7166 1981.
Harris et al TibTech 11:42 1993.
Kelly et al J Allergy Clin Immunol 91:1140-1145 1993.

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