Method of inactivating viruses in proteins

Details Method of inactivating viruses in proteins Method of inactivating viruses in proteins

1996-11-01

1999-08-03

Wortman, Donna C.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

4352351, 435236, 435239, C12N 706, C12N 700, C12N 704, C12N 702

Patent

active

059324686

ABSTRACT:
An efficient industrial method, by incubation at extreme (alkaline) pH in a stabilized medium, of inactivating viruses in general (with or without a lipid envelope) in media containing proteins for therapeutic use, without denaturing or significant loss of biological activity.

REFERENCES:
patent: 3941696 (1976-03-01), Melnick et al.
patent: 4055655 (1977-10-01), Maurer et al.
patent: 4721777 (1988-01-01), Uemura et al.
patent: 5094850 (1992-03-01), Mayr et al.
Barrowcliffe, "Virological Safety Aspects of Plasma Derivatives," In: Dev. Biol. Stand., Brown F. ed., Basel, Karger, vol. 81, p. 125-135, 1993.
Voet & Voet "Three-Dimensional Structures of Proteins", In: Biochemistry, John Wiley & Sons, New York, 1990, pp. 144-192.
Suomela, Hannu, "Inactivation of Viruses in Blood and Plasma Products," Transfusion Medicine Reviews, vol. VII, No. 1 (Jan. 1993), pp. 42-57.
Roberts, P., "Virus Safety of Plasma Products," Reviews in Medical Virology, vol 6 (1996), pp. 25-38.
Grun, Janet B., White, Elizabeth M. and Sito, Alexander F., Viral Removal Inactivation by Purification of Biopharmeceuticals, BioPharm, vol. 5, No. 9 (Nov./Dec. 1992), pp. 22-30.
Cambridge Healthtech Institute, "Blood Safety & Screening" (Third Annual), (Apr. 14-16, 1997).

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