Method of inactivating reproducible pathogens

Details Method of inactivating reproducible pathogens Method of inactivating reproducible pathogens

1984-04-30

1987-08-18

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

424101, 424 942, 424 943, 424 944, 514 2, 435236, 435185, 530381, 530383, 530384, A61K 39395, C12N 900, C12N 704

Patent

active

046876642

ABSTRACT:
There is described a method of inactivating reproducible pathogens in preparations containing plasmatic enzymes and proenzymes, activated or non-activated coagulation factors, such as Factors II, V, VII, VIII, IX, X, XIII, "FEIBA", prothrombin complex preparations, plasmatic inhibitors, immunoglobulins or other blood products, such as fibronectin and fibrinogen. In order to break and overcome the protective effect of proteins on pathogens by simultaneously preserving the biological activity and the molecular integrity of the proteins, the preparation is adjusted to a salt concentration of more than 0.5 molar by the addition of ammonium sulfate and is thermally treated, whereupon the ammonium sulfate is removed from the preparation.

REFERENCES:
patent: 3100737 (1961-11-01), Auerswald et al.
patent: 3203865 (1965-08-01), Koehler et al.
patent: 3227626 (1966-01-01), Baumgarten
patent: 3973002 (1976-08-01), Hagan et al.
patent: 4297344 (1981-10-01), Schwinn et al.
patent: 4379085 (1983-04-01), Williams et al.
patent: 4388232 (1983-06-01), Eibl et al.
patent: 4395396 (1983-07-01), Eibl et al.
patent: 4405603 (1983-09-01), Schwinn et al.
patent: 4440679 (1984-04-01), Fernandes et al.
patent: 4470968 (1984-09-01), Mitra et al.
patent: 4534972 (1985-08-01), Lembach
Miller-Anderson et al., Thrombosis Research, vol. 5, pp. 439-452, 1974.
Busby et al., J. Biol. Chem., vol. 256, pp. 12140-12147, 1981.
Fed. Proc., vol. 41, p. 763, Abstract 2877, 1982.
Austen and Rhymes; A Laboratory Manual of Blood Coagulation , pp. 50-52, 1975.
Suomela et al.; Vox Sang., vol. 33, pp. 37-50, 1977.
Odegard et al., Thrombosis Research, vol. 6, pp. 287-294, 1975.
Vogelaar et al., Vox Sang., vol. 26, pp. 118-127, 1974.
Rosen, American J. Hygiene, vol. 71, pp. 120-128, 1960.
Preston et al., J. Pathology and Bacteriology, vol. 78, pp. 209-216, 1959.
Deutsch et al., Science, vol. 170, pp. 1095-1096, 1970.
Friberger et al., Chromogenic Peptide Substrates: Chemistry and Clinical Usage, pp. 128-140, 1970.

Affiliated with

Also associated with

Rating

Method of inactivating reproducible pathogens does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of inactivating reproducible pathogens, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of inactivating reproducible pathogens will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1117105