Method of inactivating reproducible filterable pathogens in bloo

Details Method of inactivating reproducible filterable pathogens in bloo Method of inactivating reproducible filterable pathogens in bloo

1985-02-26

1987-02-03

Rosen, Sam

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424101, 514 2, A61K 37465, A61K 3748

Patent

active

046408347

ABSTRACT:
A method of inactivating viruses in blood products is described, wherein the blood products are heat-treated in a humid or in a solid state in the presence of inorganic or organic hydroxyl group-containing compounds having an H.sup.+ -dissociation constant of <10.sup.-11 in a concentration of more than 0.05 (5% by weight) and less than 0.70 (70% by weight). The hydroxyl group-containing compounds may be water, methanol, ethanol or mannitol. The temperature may amount up to 121.degree. C., the heat treatment may last from 1 s to 100 h. The inactivation method may be applied for producing blood products selected from enzymes, proenzymes including coagulation factors, enzyme inhibitors, immunoglobulins, albumin, plasminogen, fibrinogen, fibronectin or plasma, the inactivation destroying any reproducible filterable pathogens that might be present.

REFERENCES:
patent: 4160025 (1979-07-01), Eibl et al.
patent: 4379085 (1983-04-01), Williams et al.
patent: 4388232 (1983-06-01), Eibl et al.
patent: 4395396 (1983-07-01), Eibl et al.
patent: 4424206 (1984-01-01), Ohmura et al.
patent: 4440679 (1984-04-01), Fernandes et al.
patent: 4446134 (1984-05-01), Naito et al.
patent: 4481189 (1984-11-01), Prince
Webster's Third New Internat. Dictionary, (1964), p. 929.
XII Internat. Congress on Blood Transfusion, Abstracts, "MIR" Publishers, Moscow 1969, pp. 473-475.
Reed, J. L. and H. Muench; Amer. J. Hyg., 27, 493, (1983).
Scholz, E.; Fresenius', Z. anal. Chem., 314, 567-571 (1983).
Vox. Sang. 33, 37-50, (1977).
Weber and Osborn, in "The Reliability of Morecular Weight . . . ", J. Biol. Chem., 244, 4406, (1969).
Merril et al., in "Ultrasensitive Stain for Proteins . . . ", Science, 211, 1437, (1981).
Vox. Sang. 26, 118, (1974).
M. Kleindel, H. Lang, A. Philapitsch, G. Wober, "Thrombosis and Haemostasis", 50, 244, (1983).
D. G. Deutsch and E. T. Mertz, in Science, 170, 1095, (1970).
K. C. Robbins, L. Summaria, Methods in Enzymology, 19, 184-186, (1970).
U. S. Pharmacopeia, 16th Revision, (USP XVI, 1960), p. 298.
Journal of Amer. Chem. Cov., 71, 541-550, (1949).

Affiliated with

Also associated with

Rating

Method of inactivating reproducible filterable pathogens in bloo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of inactivating reproducible filterable pathogens in bloo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of inactivating reproducible filterable pathogens in bloo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1091029