Method of inactivating enveloped viruses in a viral...

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits

Reexamination Certificate

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Reexamination Certificate

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07378265

ABSTRACT:
The present invention relates to a method of inactivating enveloped viruses in a viral preparation predominantly containing non-enveloped viruses by the action of a solvent at a temperature of between −5° C. and +50° C. and at a pH of between about 5 and 9. Its subject is also a method of preparing a viral preparation comprising such a method of inactivation. The invention also relates to a viral preparation obtained according to the method of the invention. Finally, it relates to a host cell and a composition comprising such a viral preparation as well as their uses for therapeutic or prophylactic purposes.

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Huyghe, Bernard G. et al. (1995).Human Gene Therapy, 6:1403-1416.
Kopecka, Helena, “Echoviruses”, Encyclopedia of Virology, pp. 354-360.
Melnick, Joseph L. (1990). “Enteroviruses: Polioviruses, Coxsackieviruses, Echoviruses, and Newer Enteroviruses”,Fields Virology2ndEd., Ch 21, pp. 549-551, Raven Press Ltd., New York, NY, USA.

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