Method of improving solubility of tissue plasminogen activator

Details Method of improving solubility of tissue plasminogen activator Method of improving solubility of tissue plasminogen activator

1993-02-22

2000-04-18

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9464, 424 941, A61K 3849

Patent

active

060512237

ABSTRACT:
A thrombolytic composition containing tissue type plasminogen activator or a derivative thereof in combination with an anionic polymer or a salt thereof and an amine compound or a salt thereof or in combination with an anionic polymer or a salt thereof, an amine compound and an acid or a salt thereof. The composition is an aqueous solution or a lyophilized preparation which can be stably dissolved on dilution at near neutral pH in both pharmaceutical solutions having high salt concentrations, such as physiological saline, and pharmaceutical solutions having low salt concentrations, such as a 5% glucose solution. Clinically useful products for infusion or injection are prepared to be used at a pH near neutral.

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patent: 4552760 (1985-11-01), Murakami et al.
patent: 4818690 (1989-04-01), Paques
patent: 4837022 (1989-06-01), Kakimoto et al.
patent: 4898826 (1990-02-01), Duffy et al.
patent: 4980165 (1990-12-01), Isaacs et al.

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