Method of improving regeneration of transfected peripheral nerve

Details Method of improving regeneration of transfected peripheral nerve Method of improving regeneration of transfected peripheral nerve

1988-09-16

1991-11-26

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, 514 4, 514 12, A61K 3724

Patent

active

050682245

ABSTRACT:
A method for improving the regeneration of transected peripheral nerves in mammals and man, by administering a sufficient amount of insulin-like growth factor 1 (IGF-1) to a mammalian host in need of such treatment. If desired, administration of the medicament containing insulin like growth factor can be carried out locally by infusion.

REFERENCES:
Acta Physiol. Scand., 126, 1986, H. A. Hansson et al., "Evidence Indicating Trophic Importance of IG F-1 in Regenerating Peripheral Nerves", pp. 609-614.
Cell and Tissue Research, 247/1987), H.-A. Hansson et al., "Rapid Exoplasmic Transport of Insulin-Like Growth Factor I in the Sciatic Nerve of Adult Rats", pp. 241-247.
Nature, vol. 296, Mar. 18, 1982, E. Schoenle et al., "Insulin-Like Growth Factor I Stimulates Growth in Hypophysectomized Rats", pp. 252-253.
The Journal of Neuroscience, 6(5), May 1986, E. Recio-Pinto et al., "Effects of Insulin-Like Growth Factor-II, and Nerve Growth Factor on Neurite Formation and Survival in Cultured Sympathetic and Sensory Neurons", pp. 1211-1219.
Intern. J. Neuroscience, vol. 26, 1985, D. N. Ishii et al., "Neurite Formation Modulated by Nerve Growth Factor, Insulin, and Tumor Promoter Receptors", pp. 109-127.
Proc. Natl. Acad. Sci., USA, vol. 73, No. 7, Jul. 1976, E. Rinderknecht et al., "Polypeptides with Nonsuppressible Insulin-Like and Cell-Growth Promoting Activities in Human Serum: Isolation, Chemical Characterization, and Some Biological Properties of Forms I and II", pp. 2365-2369.
Proc. Natl. Acad. Sci., USA, vol. 73, No. 12, Dec. 1976, E. Rinderknecht et al., "Amino-Terminal Sequences of Two Polypeptides from Human Serum with Nonsuppressible Insulin-Like and Cell-Growth-Promoting Activities: Evidence for Structural Homology with Insulin B Chain", pp. 4379-4381.
Jour. of Neuro-Science Research 8(1982), M. Bothwell, "Insulin and Somatemedin MSA Promote Nerve Growth Factor-Independent Neurite Formation by Cultured Chick Dorsal Root Ganglionic Sensory Neurons", pp. 225-231.
Jennische et al., Acta Physiol. Scand., Jan. 1987, 129, pp. 9-15.
Hansson et al., Acta Physiol. Scand., Feb. 1987, pp. 165-169.

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