Method of improving post-ischemic myocardial function using a th

Details Method of improving post-ischemic myocardial function using a th Method of improving post-ischemic myocardial function using a th

1989-10-10

1990-12-04

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9464, 514381, 514277, A61K 3754, A61K 37547, A61K 3141, A61K 31435

Patent

active

049752790

ABSTRACT:
A method is provided for improving post-ischemic myocardial function such as contractile dysfunction or reperfusion injury by administering a thromboxane receptor antagonist which is a 7-oxabicycloheptane substituted diamide prostaglandin analog in combination with a thrombolytic agent before, during or immediately after an ischemic attack.

REFERENCES:
patent: 4661469 (1987-04-01), Sarnoff
patent: 4663336 (1987-05-01), Nakane et al.
patent: 4839384 (1989-06-01), Ogletree
Hoeft, A., et al., "Preservation of Myocardium in Transient Ischemia by the Thromboxane Synthetase Inhibitor UK-38, 485", Res. Exp. Med., 1986; 186:35-46.
Schror, K., et al., "Treatment of Acute Myocardial Ischemia with a Selective Antagonist of Thromboxane Receptors (BM13,177)", Br. J. Pharmacol., 1986; 87:631-7.
Schmitz, J. M., et al., "Vascular Prostaglandin and Thromboxane Production in a Canine Model of Myocardial Ischemia", Circ. Res., 1985; 57:223-31.
Michael, L. H., et al., "Myocardial Ischemia: Platelet and Thromboxane Concentrations in Cardiac Lymph and the Effects of Iduprofen and Prostacyclin", Circ. Res., 1986; 59:49-55.
Schumacher et al., J. Pharmacol. Exp. Ther., 277:719 (1983).
Aiken et al., J. Pharmacol. Exp. Ther., 219:299 (1981).
Schumacher et al., J. Cardiol. Pharmacol, 7:739 (1985).
Mickelson, J. K. et al., Am. Heart J., Jun., 1987, pp. 1345-1352.
Lefer, A. M., et al., "Potentiation of Myocardial Salvage by Tissue Type Plasminogen Activator in Ischemic Cat Myocardium", Circ. Res., vol. 63, No. 3, Sep. 1988.

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