Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2005-11-08
2009-11-10
Padmanabhan, Sreeni (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
C514S177000
Reexamination Certificate
active
07615544
ABSTRACT:
A method of improving cumulative embryo score may comprise administering an androgen to a human female, for example, DHEA, for at least about four consecutive months followed by harvesting and fertilizing oocytes and forming embryos. Between about 50 mg and about 100 mg of DHEA may be administered to a human female per day. Moreover, a method of increasing the quantity of fertilized oocytes in one cycle of in vitro fertilization may comprise administering an androgen to a human female for at least about four consecutive months, harvesting and fertilizing the oocytes. Furthermore, a method of increasing the quantity of day 3 embryos from one cycle of in vitro fertilization may comprise administering an androgen for at least about four consecutive months, harvesting and fertilizing the oocytes and forming day 3 embryos. A method of normalizing ovarian DHEA also may include administering an androgen for at least about four consecutive months. A method of increasing the euploidy rate in embryos may include administering an androgen for at least about four consecutive weeks.
REFERENCES:
patent: 4670401 (1987-06-01), Cutler et al.
patent: 4931403 (1990-06-01), Cutler et al.
patent: 6352997 (2002-03-01), Waldsteicher et al.
patent: 6548087 (2003-04-01), Kent et al.
Visser et al. Human Reproduction, 1993, 8, 1719-1722.
Lutz et al. PNAS, 2001, 98, 13728-13733.
Hammes S. R. Molecular Endocrinology, 2004, 18(4) 769-775 (minireview).
Genazzani et al. Fertility and Sterility, 2001, 76, 241-248.
Morales et al. Journal of Clinical Endocrinology and Metabolism, 1994, 78, 1360-1367.
Damario et al. Human Reproduction, 1997, 12, 2359-2365.
Barad et al. Fetility and Sterility, 2005, 84, 756.e1-756.e3.
Muasher S. J. Journal of Assisted reproduction and Genetics, 1993, 10, 112-114.
Lewin et al. Journal of Assisted Reproduction and Genetics, 1994, 11, 500-503.
Fasouliotis et al. Journal of Assisted Reproduction and Genetics, 2000, 17, 357-373 (review).
Barad et al. Fertility and Sterility, 2005, 84, Suppl. 1, S42 (Abstract).
Hugues J. N. Current Practices and Controversies in Assisted reproduction: Meeting report “Medical, Ethical and Social Aspects of Assisted Reproduction”, World Health Organization, Sep. 17-21, 2001, p. 102-125.
Weering et al. Human Reproduction, 2001, 16, 1537-1538 (Letters to the Editor).
Anderson et al. The Anatomical record, 1997, 249, 44-53.
Barad et al. (Fertility and Sterility, Sep. 2005, 84, Supplement 1, p. S42: Abstract).
Casson et al. (Human Reproduction, 2000, 15, 2129-2132).
Genazzani et al. (Fertility and Sterility, 2001, 76, 241-248).
MedicineNet.com (Definition of Cells, reproductive, retrieved on Apr. 3, 2008 via http://www.medterms.com).
Casson et al. (Human Reproduction, 2000, vol. 15, p. 2129-2132).
Visser et al. (Human Reproduction, 1993, vol. 8, p. 1721, Discussion section).
Aging and infertility in women: a committee opinion. Fertil Steril 2002;78(1):215-9.
Navot D, Bergh PA, Williams MA, et al. Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility. Lancet 1991;337(8754):1375-7.
Scott RT, Leonardi MR, Hofmann GE, Illions EH, Neal GS, Navot D. A prospective evaluation of clomiphene citrate challenge test screening of the general Infertility population. Obstet Gynecol 1993;82(4 Pt 1):539-44.
Scott RT, Jr. Evaluation and treatment of low responders. Semin Reprod Endocrinol 1996;14(4):317-37.
Scott RT, Jr., Hofmann GE. Prognostic assessment of ovarian reserve. Fertil Steril 1995;63(1):1-11.
Chuang CC, Chen CD, Chao KH, Chen SU, Ho HN, Yang YS. Age is a better predictor of pregnancy potential than basal follicle-stimulating hormone levels in women undergoing in vitro fertilization. Fertil Steril 2003;79(1):63-8.
Orvieto R, Bar-Hava I, Yoeli R, et al. Results of in vitro fertilization cycles in women aged 43-45 years. Gynecol Endocrinol 2004;18(2):75-8.
Zlebe S, Loft A, Petersen JH, et al. Embryo quality and developmental potential is compromised by age. Acta Obstet Gynecol Scand 2001;80(2):169-74.
Terriou P, Sapin C, Giorgetti C, Hans E, Spach JL, Rouller R. Embryo score is a better predictor of pregnancy than the number of transferred embryos or female age. Fertil Steril 2001;75(3):525-31.
Karande V, Morris R, Rinehart J, Miller C, Rao R, Gleicher N. Limited success using the “flare” protocol in poor responders in cycles with low basal follicle-stimulating hormone levels during in vitro fertilization. Fertil Steril 1997;67(5):900-3.
Schoolcraft W, Schlenker T, Gee M, Stevens J, Wagley L. Improved controlled ovarian hyperstimulation in poor responder in vitro fertilization patients with a microdose follicle-stimulating hormone flare, growth hormone protocol. Fertil Steril 1997;67(1):93-7.
Surrey ES, Bower J, Hill DM, Ramsey J, Surrey MW. Clinical and endocrine effects of a microdose GnRH agonist flare regimen administered to poor responders who are undergoing in vitro fertilization. Fertil Steril 1998;69(3):419-24.
Toner JP, Flood JT. Fertility after the age of 40. Obstet Gynecol Clin North Am 1993;20(2):261-72.
Barad D GN. Increased Oocyte Production after Treatment with Dehydroepiandrosterone. Ferility and Sterility 2005;(in press).
Steer CV, Mills CL, Tan SL, Campbell S, Edwards RG. The cumulative embryo score: a predictive embryo scoring technique to select the optimal number of embryos to transfer in an in-vitro fertilization and embryo transferprogramme Hum Reprod 1992;7(1):117-9.
Van Wagenen G, Simpson M. Embryology of the ovary and testis,Homo sapiensandMacaca mulatta. New Haven: Yale University Press; 1965.
Block E. A quantitative morphological investigations of the follicular system in newborn female infants. Acta Anat (Basel) 1953;17:201-6.
Forabosco A, Sforza C, De Pol A, Vizzotto L, Marzona L, Ferrario VF. Morphometric study of the human neonatal ovary. Anat Rec 1991;231(2):201-8.
Gougeon A. Dynamics of follicular growth in the human: a model from preliminary results. Hum Reprod 1986;1(2):81-7.
Richards JS, Russell DL, Robker RL, Dajee M, Alliston TN. Molecular mechanisms of ovulation and luteinization. Mol Cell Endocrinol 1998;145(1-2):47-54.
McGee EA, Hsueh AJW. Initial and Cyclic Recruitment of Ovarian Follicles. Endocr Rev 2000;21(2):200-14.
Hsueh AJ, Billig H, Tsafriri A. Ovarian follicle atresia: a hormonally controlled apoptotic process. Endocr Rev 1994;15(6):707-24.
Kaipia AJ, Hsueh AJ. Regulation of ovarian follicle atresia. Annu Rev Physiol 1997;59:349-63.
Robker RL, Richards JS. Hormonal Control of the Cell Cycle in Ovarian Cells: Proliferation Versus Differentiation. Biol Reprod 1998;59(3):476-82.
Harlow C, Shaw H, Hillier S, Hodges J. Factors influencing follicle-stimulating hormone—responsive steroidogenesis in marmoset granulosa cells: Effects of androgens and the stage of follicular maturity. Endocrinology 1988;122:2780-7.
Dorrington JH, Moon YS, Armstrong DT. Estradiol 17[beta] biosynthesis in cultured granulosa cells from hypophysectomized immature rats; stimulation by follicle stimulating hormone. Endocrinology 1975:97(5):1328-31.
Hillier SG, Whitelaw PF, Smyth CD. Follicular oestrogen synthesis: The ‘two-cell, two-gonadotrophin’ model revisited. Molecular and Cellular Endocrinology 1994;100(1-2):51-4.
Bonser J, Walker J, Purohit A, et al. Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production. J Endocrinol 2000:167(3):465-71.
Haning R. Jr, Hackett R, Flood C, Loughlin J, Zhao Q, Longcope C. Plasma dehydroepiandrosterone sulfate serves as a prehormone for 48% of follicular fluid testosterone during treatment with menotropins. J Clin Endocrinol Metab 1993;76(5):1301-7.
Hillier SG. Sex steroid metabolism and follicular development in the ovary. Oxford Reviews Of Reproductive Biology 1985;7:168-222.
Daniel SAJ, Armstrong DT. Androgens in the ovarian microenvironment. Seminars in Reproductive Endocrinology 1986;4(2):89-100.
Gore-Langton R, Armstrong D. Follicular steroidogenesis and its control. In: Knobil E, Neill J, eds. The Physiology
Barad David H.
Gleicher Norbert
Harben Dwyn V.
American Infertility of New York
Beem Patent Law Firm
Chui Mei-Ping
Padmanabhan Sreeni
LandOfFree
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