Method of imparting immunomodulating, antiviral or antitumor act

Details Method of imparting immunomodulating, antiviral or antitumor act Method of imparting immunomodulating, antiviral or antitumor act

1982-05-17

1984-07-03

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424253, 544265, A61K 3152, C07D47330

Patent

active

044579195

ABSTRACT:
There are prepared compounds of the formula ##STR1## where R.sup.1 is alkyl of 1 to 8 carbon atoms and R.sup.2 is the ester group of an unsubstituted monocarboxylic acid, aromatic carboxylic acid, aminocarboxylic acid, unsubstituted dicarboxylic acid, phosphoric acid, or nitric acid or a glycoside or an acetaldehyde acetal. The compounds are immunomodulators, have antiviral activity and antitumor activity and also are enzyme inhibitors. The compounds can also be used to introduce the corresponding alcohol into biological systems, in some cases with enhanced potency.

REFERENCES:
patent: 4151277 (1979-04-01), Albrecht
patent: 4221794 (1980-09-01), Simon et al.
patent: 4221910 (1980-09-01), Giner-Sorolla
patent: 4321376 (1982-03-01), Otani et al.
Sinkula, Annual Reports in Medicinal Chemistry, vol. 10, pp. 306-316, 1975.
Yoshikawa, Bull. of The Chem. Soc. of Japan, vol. 42, pp. 3505-3508, (1969).

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