Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1977-11-23
1980-12-02
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
A61K 3902
Patent
active
042371155
ABSTRACT:
There is provided a vaccine material capable of providing a substantial level of protection against infection by enterotoxogenic organisms of Escherichia coli. The protecting means comprises pili of the infecting organism. The protection is given either by administering the pili directly to the subject to be protected or to a pregnant female where protection of the newborn is desired. In the case of piglets, where there is substantially no transplacental transfer of immunity from mother to offspring, the pili are administered to mothers, who are then caused to feed the offspring to be protected, whereby the immunization is transferred via the colostrum of the mother.
REFERENCES:
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J. P. Duguid, Revista Latinoamericana de Microbiologia, vol. 7, Suppl. 13/14, Jun.-Dec. 1964, pp. 1-16, Functional Anatomy of E. coli with Special Reference to Enteropathogenic E. coli.
J. P. Duguid, Archivum Immunologiae et Therapiae Experimentalic, 16, p. 173 (1968), The Function of Bacterial Fimbriae.
G. W. Jones et al., Vet. Bull., 45, No. 11, #6067 (1975), Contribution of the K88 antigen of E. coli to enteropathogenicity; protection against disease by neutralizing the adhesive properties of K88 antigen.
G. W. Jones et al., J. Gen'l. Microbiology, 84, 135-144 (1974), The Association of K88 Antigen with Haemagglutinating Activity in Porcine Strains of E. coli.
M. Ishibashi, Chemical Abstracts 66: 27352r (1967), F pilus as f.sup.+ antigen.
S. Stirm et al., J. Bacteriology, 93, No. 2, 740-748 (1967), Episome-carried Surface Antigen K88 of E. coli.
C. Brinton, Nature, 183, 782-786, (1959), Non-Flagellar Appendages of Bacteria.
E. Stanislavskii et al., Chemical Abstracts, 60: 12534f, (1964), Antigenic properties of the cellular structures of E. coli.
Bactex, Inc.
Behr Omri M.
Daus Donald G.
Eakin M. C.
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