Method of imaging a random medium

Details Method of imaging a random medium Method of imaging a random medium

1989-06-08

1992-08-11

Rosenberger, Richard A.

Optics: measuring and testing

By particle light scattering

With photocell detection

128664, 356237, G01N 2100

Patent

active

051373556

ABSTRACT:
A non-invasive medical imaging technique capable of evaluating, in situ, the oxygenation state of body tissues (e.g., by measuring the spectral properties of heme proteins) is described. The technique is based on the measurement of scattered radiation in the near-infrared region (NIR), where significant penetration into body tissues occurs. The disclosed technique employs a multi-wavelength collimated source and a collimated receiver and performs a positional and angular scan of the scattered radiation for each position of the incident beam. The resultant data is evaluated by employing imaging schemes which give differential weights to the contribution of various volume elements (voxels) in the medium to the detector response. A three-dimensional spectroscopic image of the target medium is determined by considering the contribution of the various volume elements for each source-detector configuration and position of the incident beam at various frequencies. These measurements, in an imaging mode, yield vital physiological information while being, for example, a sensitive indicator of subtle physiological stress caused by disease or trauma.

REFERENCES:
patent: 4555179 (1985-11-01), Langerholc et al.
patent: 4810875 (1989-03-01), Wyatt
patent: 4829184 (1989-05-01), Nelson et al.
Langerholc, J. "Moving Phase Transitions in Laser-Irradiated Biological Tissue" Applied Optics vol. 18, No. 13 (Jul. 1, 1979).

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