Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-06-05
2007-06-05
Landsman, Robert S. (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S007800, C435S007900
Reexamination Certificate
active
10190866
ABSTRACT:
The present invention relates to a method to identify substances and a use of such substances which can modulate IL-4 dependent signaling involved in tumor diseases, preferably Hodgkin Lymphomas or inflammatory airway diseases, preferably asthma and a method for determining whether a substance can modulate the interaction of STAT6 with NCoA-1, characterized in thata) STAT6 or fragments or derivatives thereof having the ability to bind to NcoA-1 are brought into contact with NCoA-1 or fragments or derivatives of NCoA-1 having the ability to bind STAT6 under conditions where STAT6 and NCoA-1 or fragments or derivatives thereof are capable of forming a complex, and the complex can be used to induce a measurable readout;b) a readout is measured in the absence or presence of the substance of interest;c) the readout in absence of substance of interest is compared with readout in presence of substance of interest.
REFERENCES:
patent: WO 99 10493 (1999-03-01), None
patent: WO 99 41608 (1999-08-01), None
patent: WO 99 50283 (1999-10-01), None
Rudlinger et al, Characteristics of amino acids as components of a peptide hormone sequence, Peptide Hormone, Oct. 29, 1976, p. 1-7.
Svaren, J. et al: “The Nab2 and Stat6 genes share a common transcription termination region” Genomics, 1997, 41(1):33-39.
Abstract XP-002228754 “STAT 6 (Fragment)”.
Litterst, et al; “Transcriptional Activation by STAT6 Requires the Direct Interaction with NCoA-1*”; J. Biol. Chem., vol. 276, No. 49; 2001; p. 45713-45721.
Litterst Claudia Monika
Pfitzner Edith
Boehringer Ingelheim Corporation
Bottino Anthony P.
Devlin Mary-Ellen M.
Hissong Bruce D.
Landsman Robert S.
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