Method of identifying sequence in a nucleic acid target using in

Details Method of identifying sequence in a nucleic acid target using in Method of identifying sequence in a nucleic acid target using in

1995-10-20

1997-11-04

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

436 94, 436501, 436808, 935 77, 935 78, 536 243, C12Q 168, G01N 3348, C07H 2104

Patent

active

056838816

ABSTRACT:
A new approach is proposed for sequencing by hybridization (SBH), which uses interaction to dramatically reduce the number of oligonucleotides used for de novo sequencing of large DNA fragments, while preserving the parallelism which is the primary advantage of SBH. In particular, a series of rounds is performed, starting from an initial fixed oligonucleotide array, of hybridizing a target sample against an array, and then designing a new oligonucleotide array in response to the results of the rounds to date, until the sequence is determined.

REFERENCES:
patent: 5002867 (1991-03-01), Macevicz
Chetverin and Kramer Bio/Technology 12:1093-1099 Nov. 1994.
Skiena and Sundaram J. Computational Biology 2(2):333-353 Summer 1995.
Drmanac et. al. Genomics 4:114-128 (1989).
Broude et. al. Proceedings of the National Academy of Science, USA 91:3072-3076 (Apr. 1994).

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