Method of identifying persons susceptible to autoimmune neuropsy

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 71, 435 721, 435 72, 435 77, 435 79, 435 792, 435960, 435 793, 435 794, 435 795, 435343, 4353431, 436501, 436506, 436514, 436536, 436811, 53038822, 5303887, 53038873, 53038885, 5303896, 5303913, 5303911, G01N 3353, G01N 33564, G01N 33543, G01N 33577

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active

058663479

ABSTRACT:
A method of identifying individuals who have, or who are at risk of developing, autoimmune neuropsychiatric disorders is disclosed. The invented method relies on detection of the B lymphocyte antigen, D8/17. The invented method can conveniently be carried out as a simple blood test.

REFERENCES:
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Susan E. Swedo, MD; Sydenham's Chorea A Model for Childhood Autoimmune Neuropsychiatric Disorders: JAMA, Dec. 14, 1994 -vol. 272, No. 22, pp. 1788-1791.
Harvey S. Singer; Neurobiological Issues in Tourette Syndrome; Brain and Development vol. 16: 353-364, 1994.
Susan E. Swedo, MD et al.; Sydenham's Chorea: Physical and Psychological Symptoms of St Vitus Dance; Pediatrics vol. 91 No. 4; Apr. 1993, pp. 706-713.
Susan E. Swedo, MD, Henrietta L. Leonard, MD, and Judith L. Rapoport, MD; Childhood-Onset Obsessive Compulsive Disorder; Psychiatric Clinic of North America, vol. 15 No. 4; Dec. 1992, pp. 767-775.
G.V.H. Herdy, J.B. Zabriskie, F. Chapman, A. Khanna and S. Swedo; A Rapid Test For the Detection of A B-Cell Marker (D8/17) In Rheumatic Fever Patients, Brazil. J. Med. Biol. Re., 25:789-794, 1992.
Allan Gibofsky, Ashwani Khanna, Elsa Suh, and John B. Zabriskie; The Genetics of Rheumatic Fever: Relationship to Streptococcal Infection and Autoimmune Disease. J. Rheumatol., 18: 1-5, 1991.
A. Khanna, D. Buskirk, R. Williams, A. Gibofsky, M. Crow, A. Menon, M. Fotino, H. Reid, T. Poon-King, P. Rubinstein and J. Zabriskie; Presence of a non-HLA B Cell Antigen In Rheumatic Fever patients and their families as defined by a monoclonal antibody. J. Clin. Invest., 83: 1710-1716, 1989.
A.J. Allen, M.D., Ph.D., et al.; Case Study: A New Infectious-Triggered, Autoimmune Subtype of Pediatric OCD and Tourette's Syndrome; J. Am. Acad. Child Adolesc. Psychiatry, vol. 34, No. 3, Mar. 1995, pp. 307-311.
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Seaver, Gen. Eng. News, 14:10,21, 1994.

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