Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2003-01-13
2008-09-09
Naff, David M (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C530S402000, C530S412000, C530S815000, C530S816000
Reexamination Certificate
active
07422865
ABSTRACT:
The present invention provides a new and improved method for reducing the complexity of a proteomic sample, and preferably also for allowing identification of proteins in the sample. In one aspect, the invention provides a highly efficient method for identifying proteins in a proteomic sample by characterizing a single N-terminal peptide per protein. In another aspect, the invention provides a method for identifying proteins in a proteomic sample by characterizing a single C-terminal peptide per protein. In another aspect, the present invention provides a method for quantitative determination of differential protein expression and/or modification in different samples. In another aspect, the invention relates to kits useful for conveniently performing a method in accordance with the invention.
REFERENCES:
patent: 5240859 (1993-08-01), Aebersold
patent: 5538897 (1996-07-01), Yates, III et al.
patent: 5856082 (1999-01-01), Aebersold et al.
patent: 6064754 (2000-05-01), Parekh et al.
patent: 6225047 (2001-05-01), Hutchens et al.
patent: 6278794 (2001-08-01), Parekh et al.
patent: 6316267 (2001-11-01), Bhalgat et al.
patent: 6322970 (2001-11-01), Little et al.
patent: 6329209 (2001-12-01), Wagner et al.
patent: 6331400 (2001-12-01), Woods, Jr.
patent: 7052915 (2006-05-01), Aebersold et al.
patent: 2001/0039016 (2001-11-01), Waldman et al.
patent: 2002/0106700 (2002-08-01), Foote et al.
patent: WO 00/11208 (2000-03-01), None
patent: WO 01/96869 (2001-12-01), None
patent: WO 02/077016 (2002-10-01), None
patent: WO 02/097703 (2002-12-01), None
patent: WO 02/097703 (2002-12-01), None
Aebersold, et al., “Equipping Scientists for the New Biology”, Nature Biotechnology, 18:359, 2000.
Anderson, et al., “Proteomics: Applications in Basic and Applied Biology”, Current Opinion in Biotechnology, 11: 408-412, 2000.
Appella, et al., “Meeting Report”, Protein Science, 10: 459-461, 2001.
Ashman, et al., “Cell Signalling—The Proteomics of it All”, Sciences STKE, p. 1-6.
Beardsley, et al., “Enhancing the Intensities of Lysine-Terminated Tryptic Peptide Ions in Matrix-Assisted Laser Desorption/Ionization Mass Sepctrometry”, Rapid Communications in Mass Spectrometry, 14: 2147-2153, 2000.
Chich, J., “A Mini Review: Proteomic Analysis, a Post-Genomic Approach”, Lait, 81:13-18, 2001.
Dutt, et al., “Proteomic Analysis”, Current Opinion in Biotechnology, 11: 176-179, 2000.
Eng, et al., “An Approach to Correlate Tandem Mass Spectral Data of Peptides with Amino Acid Sequences in a Protein Database”, J. Am. Soc. Mass. Spectrom, 5: 976-989, 1994.
Ewing, et al., “Peptide Fingerprinting on the OmniFLEX: Bench-Top Protein Identification”, Bruker Daltonics, Inc., pp. 1-6.
Gygi, et al., “Measuring Gene Expression by Quantitative Proteome Analysis”, Current Opinion in Biotechnology, 11: 396-401, 2000.
Keough, et al., “A Method for High-Sensitivity Peptide Sequencing Using Postsource Decay Matrix-Assisted Laser Desorption Ionization Mass Sepctrometry”, Proc. Natl. Acad. Sci. USA, 96: 7131-7136, 1999.
Mann, M., “Quantitative Proteomics?”, Nature Biotechnology, 17: 954-955, 1999.
McCormack, et al., “Direct Analysis and Identification of Proteins in Mixtures by LC/MS/MS and Database Searching at the Low-Femtomole Leve”, Anal. Chem. 69: 767-775, 1997.
Pandey, et al., “Proteomics to Study Genes and Genomes”, Nature, 405: 837-846, 2000.
Peters, et al., “A Novel Multifunctional Labeling Reagent for Enhanced Protein Characterization with Mass Spectrometry”, Rapid Communications in Mass Spectrometry, 15:2387-2392, 2001.
Rapp, et al., “Detection Limits of MALDI-TOF PSD for Peptide Sequencing from Protein Digests”, Bruker Daltonics, pp. 1-6, 2000.
Shim, et al., “PepAssem, A Peptide Assembly Algorithm for a Complex Protein Mixture”, Genome Informatics, 12: 366-367, 2001.
Suckau, et al., “Automation of MALDI-TOF Analysis for Proteomics”, Bruker Daltonics, pp. 1-5, 1999.
Suckau, et al., “N-Terminal Derivatization of Tryptic Peptides for de Novo Sequencing by PSD: A Powerful New Tool in Proteomics”, Bruker Daltonics, pp. 1-4, 2000.
Swiderek, et al., “The Identification of Peptide Modifications Derived from Gel-Seperated Proteins Using Electrospray Triple Quadrupole and Ion Trap Analyses”, Electrophoresis, 19: 989-997, 1998.
Tang, et al., “An Automated C-Terminal Sequencing Method for Analysis of Proteins Using an ABI 473A Sequencer” J. Biomol Tech. 10: 144-148, 1999.
Wilkins, et al., “Rapid Protein Identification Using N-Terminal “Sequence Tag” and Amino Acid Analysis”, Biochemical and Biophysical Research Communications, 221: 609-613, 1996.
Cagney et al., Title: “De Novo Peptide Sequencing And Quantitative Profiling Of Complex Protein Mixtures Using Mass-Coded Abundance Tagging”, Nature, 2002, pp. 163-170.
Gevaert et al., Title: “Chromatographic Isolation Of Methionine-Containing Peptides For Gel-Free Proteome Analysis”, Molecular & Cellular Proteomics, 2002, pp. 896-903.
Gevaert et al., Title: “Exploring Proteomes And Analyzing Protein Processing By Mass Spectrometric Identification Of Sorted N-Terminal Peptides”, Nature, 2003, pp. 566-569.
European Search Report dated: Apr. 8, 2004.
Agilent Technologie,s Inc.
Naff David M
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