Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-09-18
2007-09-18
O'Hara, Eileen B. (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C514S002600, C424S009200, C530S350000, C530S300000, C530S388220
Reexamination Certificate
active
10466258
ABSTRACT:
A method of identifying a modulator Nogo function, the method comprising:(i) providing(a) a BACE polypeptide;(b) a Nogo polypeptide;(c) a test agentunder conditions that would permit binding of a BACE polypeptide (a) to a Nogo polypeptide (b) in the absence of the test agent (c) wherein said BACE polypeptide (a) is BACE or a variant thereof or a fragment of either thereof capable of binding Nogo; and polypeptide (b) is Nogo or a variant thereof or a fragment of either thereof capable of binding BACE;(ii) monitoring Nogo mediated activity; and(iii) determining thereby whether the test agent is a modulator of Nogo activity.Modulators identified by a method of the invention and use of such modulators in the manufacture of a medicament for the treatment of disorders responsive to the modulation of Nogo activity such as acute neuronal injury.
REFERENCES:
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Blackstock Walter Philip
Hale Richard Stephen
Prinjha Rabinder
Rowley Adele
Campen Virginia G.
Glaxo Group Limited
O'Hara Eileen B.
SmithKline Beecham plc
Wegert Sandra
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