Method of identifying MHC-class I restricted antigens endogenous

Details Method of identifying MHC-class I restricted antigens endogenous Method of identifying MHC-class I restricted antigens endogenous

1996-03-12

1998-08-11

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 435 721, 435 722, 435 723, 435 724, 435 732, G01N 3353, G01N 33569

Patent

active

057926042

ABSTRACT:
A method of identifying antigens which are capable of being endogenously processed by a cellular secretory pathway comprising: introducing an antigen into a donor cell lacking in MHC class I molecules, incubating in an in vitro medium the donor cells, primed cytotoxic T lymphocytes having specificity for the antigen, and target cells which express MHC class I molecules and are labelled with a detectable intracellular marker, under suitable conditions such that the donor cells remain intact, and measuring the amount of detectable marker released into the incubation medium. A method of assaying a medium for the presence of a substance that affects processing of an endogenously processed antigen in a cellular secretory pathway, and; a method of characterizing a tumor or viral antigen capable of being endogenously processed by a cellular secretory pathway.

REFERENCES:
van Bleek and Nathanson, Nature, 348:213, 1990.
Zhang et al., Proc. Natl. Acad. Sci. USA, 89:8403, 1992.
Matsumura et al., Science, 257:927, 1992.
Latron et al., Science, 257:964, 1992.
Nuchtem et al., Nature, 339:223, 1989.
Yewdell and Bennink, Science, 244:1072, 1989.
Cox et al., Science, 247:715, 1990.
Deverson et al., Nature, 348:738, 1990.
Trowsdale et al, Nature, 348:741, 1990.
Spies et al., Nature, 348:744, 1990.
Monaco et al., Science, 250:1723, 1990.
Spies and DeMars, Nature, 351:323, 1991.
Bahram et a l., Proc. Natl. Acad. Sci. USA, 88:10094, 1991.
Spies et al., Nature, 355:644, 1992.
Kelly et al., Nature, 355:641, 1992.
Powis et al., Proc. Natl. Acad. Sci. USA, 89:1463, 1992.
Colonna et al., Proc. Natl. Acad. Sci. USA, 89:3932. 1992.
Monaco and McDevitt, Proc. Natl.Acad. Sci. USA, 79:3001. 1982.
Ortiz-Navarette et al.,Nature, 353:662, 1991.
Brown et al., Nature 353:355, 1991.
Glynne et al., Nature 353:357, 1991.
Martinez and Monaco, Nature, 353:664, 1991.
Kelly et al., Nature, 353:667, 1991.
Yang et al., Proc. Natl. Acad. Sci. USA, 89:4928, 1992.
Goldberg and Rock, Nature, 357:375, 1992.
Falk et al., Nature, 348:248, 1990.
Rotzschke et al., Nature, 348:252, 1990.
Arnold et al., J. Exp. Med., 182:885, 1995.
Udono and Srivastava, J.Exp. Med., 178:1391, 1993.
Udono and Srivastava, J. Immunol., 152:5398, 1994.
Huang et al., Science, 264:961, 1994.
Sinha et al., Science, 248:1380, 1990.
Rammensee et al., Immunogenetics, 41:178, 1995.
Restifo et al., J. Exp. Med., 177:265,1993.
Williams et al., J. Immunol., 142:2796, 1989.
Rock et al., J. Immunol. 150:1244, 1993.
Moss, Seminars in Immunol. 2:317, 1990.
Ossevoort et al., Eur. J. Immunol. 23:3082, 1993.
Jefferies et al., J. Immunol., 151:2974, 1993.
Townsend et al., Nature, 340:443-448, 1989.
Yang et al., J. Biol. Chem., 267:11669-11672, 1992.
Driscoll et al., Nature, 365:262, 1993.
Hunt et al., Science, 255:1261-1263, 1992.
Henderson et al., Science, 25:1264-1266, 1992.
Moskophidis et al., nature 362:758-761, 1993.
Bevan, M.J., J. Exp. Med., 143:1283-1288, 1976.
Karre et al., Nature, 319:675-678, 1986.
Falk et al., Cell. Immunol., 150:447-452, 1993.
Rotam-Yehudar eta l., J. Exp. Med., 180:477-488, 1994.
Brown et al., J. Immunol., 151:1193-1204, 1993.
Wallny et al., Eur. J. Immunol. 22:655-659, 1992.
Elliott et al., Nature, 348:195-197, 1990.
Michalek et al., Nature, 363:552-554, 1993.
Sebzda et al., Science, 263:1615-1617, 1994.
Hogquist et al., Cell, 76:17-27, 1994.
Gaczynska et al., Nature 365:264-267,1993.
von Boehmer, Nature, 362:696, 1993.
R. Suto et al, Science, 269, 1585-1588, 1995.

Affiliated with

Also associated with

Rating

Method of identifying MHC-class I restricted antigens endogenous does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of identifying MHC-class I restricted antigens endogenous, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying MHC-class I restricted antigens endogenous will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-387845