Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis
Reexamination Certificate
2008-05-06
2008-05-06
Smith, Carolyn L. (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Chemical analysis
C702S019000, C435S007100, C435S069200, C435S183000
Reexamination Certificate
active
07369946
ABSTRACT:
The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Tie-2. The invention also relates to the use of the three dimensional structure of the Tie-2 catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Tie-2 activity, for example, compounds which inhibit the binding of a native substrate to the Tie-2 catalytic domain.
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Allen Karen
Arnold Lee D.
Bellamacina Cornelia
Bump Nancy J.
Dixon Richard W.
Abbott & GmbH & Co. KG
O'Brien Gayle B.
Smith Carolyn L.
Zwicker Kenneth P.
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