Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2006-08-17
2008-10-21
Tsang, Cecilia J (Department: 1654)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C435S007100, C435S007230
Reexamination Certificate
active
07438892
ABSTRACT:
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
REFERENCES:
patent: 6613318 (2003-09-01), Wang et al.
patent: 7005419 (2006-02-01), Wang et al.
patent: 7125890 (2006-10-01), Dellaria et al.
patent: 2006/0088888 (2006-04-01), Wang et al.
patent: 2006/0280683 (2006-12-01), Wang et al.
Coursen Jill D.
Fornace Albert J.
Harris Curtis C.
Wang Xin Wei
Zhan Qimin
Cordero Garcia Marcela M
The United States of Americas as represented by the Secretary of
Townsend and Townsend / and Crew LLP
Tsang Cecilia J
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