Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-05-23
1998-06-02
Green, Lora M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 23, 435 24, 436501, 436174, 436175, 436817, G01N 3353, G01N 3374
Patent
active
057597855
ABSTRACT:
The present invention provides a novel method of determining the antagonist and agonist activity of a compound for steroid hormone receptors. The present invention also provides a method of determining antagonist activity of a compound for a hormone receptor by inducing the conformational change in the receptor. In addition, the present invention provides a novel method of determining the level of agonist activity of a compound for steroid hormone receptors.
REFERENCES:
Ronald M. Evans, The Steroid and Thyroid Hormone Receptor Superfamily, 240 Science 889 (1988).
J.W.R. Schwabe and D. Rhodes, Beyond zinc fingers: steroid hormone receptors have a novel structural motif for DNA recognition, 16 Trends in Biochem. Sci. 291 (1991).
P.J. Fuller, The steroid receptor superfamily: mechanisms of diversity, 5 F.A.S.E.B. 2092 (1991).
V. Giguere et al., "Functional Domains of the Human Glucocorticoid Receptor", Cell, vol. 46, pp. 645-652, Aug. 29, 1986.
R. Heyman et al., "9-Cis Retinoic Acid Is a High Affinity Ligand for the Retinoid X Receptor", Cell, vol. 68, pp. 397-406, Jan. 24, 1992.
M. Bagchi et al., Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro, Proc. Natl. Acad. Sci. USA, vol. 89, pp. 2664-2668, Apr. 1992.
D. Picard et al., "A Movable and Regulable Inactivation Function within the Steroid Binding Domain of the Glucocorticoid Receptor", Cell. vol. 54, pp. 1073-1080, Sep. 23, 1988.
Iyengar et al J. Biol. Chem: 259 (1984) pp. 5222-5229.
Sabbah et al Proc. Natl. Acad. Sci. 88 (Jan. 1991) pp. 390-394.
Evans Science 240 (1988) pp. 889-895.
Friguct et al in Protein Structure ed Creighton IRL Press (1990) p. 309.
Cantor et al Biophysical Chemistry: Techniques for the Study of Biological Structure & Function W.H. Freeman & Co. (1980) pp. 443-448.
Allan George Francis
O'Malley Bert W.
Tsai Ming-Jer
Tsai Sophia Yang
Baylor College of Medicine
Green Lora M.
LandOfFree
Method of identifying hormone antagonists and agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of identifying hormone antagonists and agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying hormone antagonists and agonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1458379