Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-10-27
2008-10-28
Whisenant, Ethan (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024300
Reexamination Certificate
active
07442510
ABSTRACT:
Methods of identifying molecular beacons in which a secondary structure prediction algorithm is employed to identify oligonucleotide sequences within a target gene having the requisite hairpin structure. Isolated oligonucleotides, molecular beacons prepared from those oligonucleotides, and their use are also disclosed.
REFERENCES:
patent: 5215899 (1993-06-01), Dattagupta
patent: 5556749 (1996-09-01), Mitsuhashi et al.
patent: 5925517 (1999-07-01), Tyagi et al.
patent: 6114121 (2000-09-01), Fujiwara et al.
patent: 6194155 (2001-02-01), Cohen
patent: 6251588 (2001-06-01), Shannon et al.
patent: 6277607 (2001-08-01), Tyagi et al.
patent: 6312906 (2001-11-01), Cass et al.
patent: 6355437 (2002-03-01), Neri et al.
patent: 6365729 (2002-04-01), Tyagi et al.
patent: 6380377 (2002-04-01), Dattagupta
patent: 7070933 (2006-07-01), Browne
patent: 2003/0013109 (2003-01-01), Ballinger et al.
patent: 2003/0054346 (2003-03-01), Shannon et al.
patent: 2003/0143535 (2003-07-01), Lyamichev et al.
patent: 00/43552 (2000-07-01), None
Bonnet et al., “Thermodynamic Basis of the Enhanced Specificity of Structured DNA Probes,”Proc. Natl. Acad. Sci. USA96:6171-6176 (1999).
Du et al., “Hybridization-Based Unquenching of DNA Hairpins on Au Surfaces: Prototypical “Molecular Beacon” Biosensors,”J. Am. Chem. Soc. 125:4012-4013 (2003).
Dubertret et al., “Single-Mismatch Detection Using Gold-Quenched Fluorescent Oligonucleotides,”Nat. Biotech. 19:365-370 (2001).
Broude, “Stem-loop Oligonucleotides: A Robust Tool for Molecular Biology and Biotechnology,” Trends in Biotechnology 20(6):249-56 (2002).
Elsayed et al., “Development and Validation of a Molecular Beacon Probe-Based Real-Time Polymerase Chain Reaction Assay for Rapid Detection of Methicillin Resistance inStaphylococcus aureus,” Arch. Pathol. Lab. Med. 127:845-9 (2003).
Kushon et al., “Effect of Secondary Structure on the Thermodynamics and Kinetics of PNA Hybridization to DNA Hairpins,” J. Am. Chem. Soc. 123(44):10805-13 (2001).
Park et al., “Rapid Identification ofCandida dubliniensisUsing a Species-Specific Molecular Beacon,” Journal of Clinical Microbiology 38(8):2829-36 (2000).
Riccelli et al., “Hybridization of Single-stranded DNA Targets to Immobilized Complementary DNA Probes: Comparison of Hairpin Versus Linear Capture Probes,” Nucelic Acids Research 29(4):996-1004 (2001).
Miller Benjamin L.
Strohsahl Christopher M.
Nixon & Peabody LLP
University of Rochester
Whisenant Ethan
LandOfFree
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