Method of identifying compounds using a transgenic pig model...

Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...

Reexamination Certificate

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C800S009000, C800S017000

Reexamination Certificate

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07989675

ABSTRACT:
The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of therapies for the diseases and conditions.

REFERENCES:
patent: 6215041 (2001-04-01), Stice et al.
patent: 6271436 (2001-08-01), Piedrahita et al.
patent: 6503698 (2003-01-01), Dobrinsky et al.
patent: 6700037 (2004-03-01), Damiani et al.
patent: 7291461 (2007-11-01), Welch et al.
patent: 2005/0120400 (2005-06-01), Day et al.
patent: 2006/0041945 (2006-02-01), Robl et al.
patent: 2009/0241203 (2009-09-01), Welsh et al.
patent: WO 96/07732 (1996-03-01), None
patent: WO 99/36510 (1999-07-01), None
patent: WO 01/03722 (2001-01-01), None
patent: WO 2005/104835 (2005-11-01), None
patent: WO 2008/121199 (2008-10-01), None
Rogers (J. Clin. Investigation, Apr. 2008, vol. 118, No. 4, p. 1571-1577).
Harris (Human Mol Genetics, 1997, vol. 6, No. 13, p. 2191-2193).
Li (Reproductive Biol. & Endocrin., 2003, vol. 1, 83, p. 1-8).
Sun (J. Clin. Investigation, Apr. 2008, vol. 118, No. 4, p. 1578-1583).
Rogers (Am J Physiol Lung Cell Mol Physiol, May 16, 2008, vol. 295, p. 240-263).
Welsh (Transactions of the Am. Clin. And Climatological Assoc. 2009, vol. 120, p. 149-162).
Meyerholz (Am. J. Pathol., Mar. 2010, vol. 176, No. 3, p. 1377-1389).
Richt (Nature Biotech, Jan. 2007, vol. 25, No. 1, p. 132-139).
van Heeckeren (Am J Physicol Lung Cell Mol Physiol, 2004, vol. 287, p. 944-952).
U.S. Appl. No. 60/908,637, filed Mar. 28, 2007, Welsh et al.
U.S. Appl. No. 60/966,971, filed Aug. 30, 2007, Welsh et al.
U.S. Appl. No. 12/283,980, filed Sep. 17, 2008, Welsh et al.
Grosse-Hovest et al., “Cloned Transgenic Farm Animals Produce a Bispecific Antibody for T Cell-Mediated Tumor Cell Killing,” Proc. Natl. Acad. Sci. U.S.A. 101:6858-6863, 2004.
Harris, “Towards an Ovine Model of Cystic Fibrosis,” Hum. Mol. Genet. 6:2191-2193, 1997.
Hirata et al., “Efficient PRNP Gene Targeting in Bovine Fibroblasts by Adeno-Associated Virus Vectors,” Cloning Stem Cells 6:31-36, 2004.
Hao et al., “Production of Endothelial Nitric Oxide Synthase (eNOS) Over-Expressing Piglets,” Transgenic Res. 15:739-750, 2006.
Inoue et al., “High-Fidelity Correction of Mutations at Multiple Chromosomal Positions by Adeno-Associated Virus Vectors,” J. Virol. 73:7376-7380, 1999.
Kelley et al, “In Vivo Activation of the Cystic Fibrosis Transmembrane Conductance Regulator Mutant Δ,F508 in Murine Nasal Epithelium,” Proc. Natl. Acad. Sci. U.S.A. 94:2604-2608, 1997.
Lai et al., “Production of α-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning,” Science 295:1089-1092, 2002.
Lai et al., “Creating Genetically Modified Pigs by Using Nuclear Transfer,” Reprod. Biol. Endocrinol. 1:1-6, 2003.
Lai et al., “Production of Cloned Pigs by Using Somatic Cells as Donors,” Cloning and Stem Cells 5:233-241, 2003.
Lai et al., “A Method for Producing Cloned Pigs by Using Somatic Cells as Donors,” Methods Mol. Biol. 254:149-163, 2004.
Lai et al., “Generation of Cloned Transgenic Pigs Rich in Omega-3 Fatty Acids,” Nat. Biotechnol. 24:435-436, 2006.
Li et al., “Progress Toward Generating a Ferret Model of Cystic Fibrosis by Somatic Cell Nuclear Transfer,” Reprod. Biol. Endocrinol. 1:1-8, 2003.
Li et al., “Cloned Transgenic Swine Via in Vitro Production and Cryopreservation,” Biol. Reprod. 75:226-230, 2006.
Liu et al., “Targeted Correction of Single-Base-Pair Mutations with Adeno-Associated Virus Vectors under Nonselective Conditions,” J. Virol. 78:4165-4175, 2004.
Liu et al., “Mild Processing Defect of Porcine ΔF508-CFTR Suggests that ΔF508 Pigs May not Develop Cystic Fibrosis Disease,” Biochem. Biophys. Res. Comm. 373:113-118, 2008.
Ostedgaard et al., “Processing and Function of CFTR-ΔF508 are Species-Dependent,” Proc. Natl. Acad. Sci. U.S.A. 104:15370-15375, 2007.
Park et al., “Production of Nuclear Transfer-Derived Swine that Express the Enhanced Green Fluorescent Protein,” Animal Biotechnol. 12:173-181, 2001.
Park et al., “Developmental Potential of Porcine Nuclear Transfer Embryos Derived from Transgenic Fetal Fibroblasts Infected with the Gene for the Green Fluorescent Protein: Comparison of Different Fusion/Activation Conditions,” Biol. Reprod. 65:1681-1685, 2001.
Prather et al., “Nuclear Remodeling and Reprogramming in Transgenic Pig Production,” Exp. Biol. Med. 229:1120-1126, 2004.
Reynaert et al., “Morphological Changes in the Vas Deferens and Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Control, ΔF508 and Knock-Out CFTR Mice During Postnatal Life,” Mol. Reprod. Dev. 55:125-135, 2000.
Rogers et al., University of Iowa, College of Medicine Research Week poster, Mar. 29, 2006 (also presented in substantially similar form on Feb. 23, 2006 at University of Iowa, Department of Internal Medicine Research Day, Feb. 23, 2006, with the exception of Figure 7).
Rogers et al., University of Iowa, Gene Therapy Center Retreat presentation, Apr. 26, 2006.
Rogers et al., “Gene Targeting of Pig CFTR: Progress Toward a Large Animal Model of Cystic Fibrosis,” North American Cystic Fibrosis Meeting, 2006, Ped. Pulm. 41 S29, abstract 231, 2006.
Rogers et al., “Production ofCFTR-Null andCFTR-ΔF508 Heterozygous Pigs by Adeno-Associated Virus-Mediated Gene Targeting and Somatic Cell Nuclear Transfer,” J. Clin. Invest. 118:1571-1577, 2008.
Rogers et al., “The Porcine Lung as a Potential Model for Cystic Fibrosis,” Am. J. Physiol. Lung Cell Mol. Physiol. 295:L240-L263, 2008.
Verkman, “From the Farm to the Lab: the Pig as New Model of Cystic Fibrosis,” Am. J. Physiol. Lung Cell Mol. Physiol. 295:L238-L239, 2008.
Yan et al., “Ubiquitination of Both Adeno-Associated Virus Type 2 and 5 Capsid Proteins Affects the Transduction Efficiency of Recombinant Vectors,” J. Virol. 76:2043-2053, 2002.
International Search Report from International Application No. PCT/US2008/002886, dated Aug. 21, 2008 (date of completion of the search) and Sep. 15, 2008 (date of mailing of report).
Written Opinion from International Application No. PCT/US2008/002886, dated Aug. 25, 2008 (date of completion of opinion) and Sep. 15, 2008 (date of mailing of opinion).
International Preliminary Report on Patentability from International Application No. PCT/US2008/002886, dated Aug. 25, 2008 (date of completion of opinion) and Sep. 29, 2009 (date of issuance of report).
Restriction Requirement dated Oct. 29, 2009 from U.S. Appl. No. 12/283,980.
Reply to Restriction Requirement dated Oct. 29, 2009 from U.S. Appl. No. 12/283,980, filed Jan. 29, 2010.
Information Disclosure Statement and Form PTO 1449 from U.S. Appl. No. 12/283,980, filed Jan. 29, 2010.
Office Action dated Mar. 2, 2010 from U.S. Appl. No. 12/283,980.
Reply to Office Action dated Mar. 2, 2010 from U.S. Appl. No. 12/283,980, filed Aug. 23, 2010.
Office Action dated Oct. 29, 2010 from U.S. Appl. No. 12/283,980.

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