Method of identifying compounds that bind to the insect gaba rec

Details Method of identifying compounds that bind to the insect gaba rec Method of identifying compounds that bind to the insect gaba rec

1996-12-17

1998-12-29

Walsh, Stephen

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435325, 435348, 4353201, 4352523, 43525411, 435 691, 530350, G01N 33566, C07K 14435, C12N 510, C12N 1563

Patent

active

058540024

ABSTRACT:
The present invention provides a method of measuring the ability of a compound to bind to the GABA recognition site of an insect GABA receptor. The invention further provides host cells that express a nucleic acid encoding the GABA receptor subunit LCCH3 and a nucleic acid encoding the GABA receptor subunit Grd, and cell membranes obtained from the host cells.

REFERENCES:
patent: 5487976 (1996-01-01), Soderlund et al.
Zhang et al., Subunit composition determines picrotoxin and bicuculline sensitivity of Drosophila gamma-aminobutyric acid receptors, Mol. Pharmacol., 48(5):835-40, Nov. 1995.
Lee et al., Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression of insecticide susceptible and resistant GABA receptors from the cyclodiene resistance gene Rdl, FEBS Lett., 335(3): 315-318, 1993.
Bloomquist (1996) Annu. Rev. Entomol. 41:163.
Ffrench-Constant et al. (1991) Proc. Nat'l Acad. Sci. USA 88:7209.
Ffrench-Constant et al. (1993) Nature 363:449.
Harvey et al. (1994) J. Neurochem. 62:2480.
Henderson et al. (1993) Biochem. Biophys. Res. Commun. 193:474.
Lunt et al. (1985) Neurochem. Int. 7:751.
Millar et al. (1994) Proc. R. Soc. Lond. 258:307.

Affiliated with

Also associated with

Rating

Method of identifying compounds that bind to the insect gaba rec does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of identifying compounds that bind to the insect gaba rec, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying compounds that bind to the insect gaba rec will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1423402