Method of identifying chemical agents which stimulate...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007200, C435S069100, C435S252300

Reexamination Certificate

active

07314723

ABSTRACT:
The present invention provides methods for identifying agents which modulate mosquito odorant receptors. The methods disclosed herein use genetic material of mosquito odorant receptors to express those receptors in a foreign host system in which the endogenous receptors have been removed.

REFERENCES:
patent: 4663346 (1987-05-01), Coulston et al.
patent: 5011909 (1991-04-01), Borovsky et al.
patent: 5030722 (1991-07-01), Snyder et al.
patent: 5128246 (1992-07-01), Snyder et al.
patent: 5130253 (1992-07-01), Borovsky et al.
patent: 5439821 (1995-08-01), Borovsky et al.
patent: 5501976 (1996-03-01), Borovsky et al.
patent: 5629196 (1997-05-01), Borovsky et al.
patent: 5670354 (1997-09-01), Burns et al.
patent: 5702916 (1997-12-01), Molin et al.
patent: 5759538 (1998-06-01), Donovan et al.
patent: 5993778 (1999-11-01), Firestein et al.
patent: 6008046 (1999-12-01), Ffrench-Constant et al.
patent: 6071878 (2000-06-01), Delecluse et al.
patent: 6610511 (2003-08-01), Carlson
patent: 2002/0064817 (2002-05-01), Buck et al.
patent: 2003/0045472 (2003-03-01), Axel et al.
patent: 2003/0082637 (2003-05-01), Zwiebel
patent: 2003/0143679 (2003-07-01), Vosshall et al.
patent: 2003/0166013 (2003-09-01), Zwiebel
patent: 2003/0186359 (2003-10-01), Vosshall et al.
patent: 2004/0003419 (2004-01-01), Carlson
patent: WO 03/020913 (2003-03-01), None
Blackwell et al. (2000). Electrophysiological investigation of larval water and potential oviposition chemo-attractants for Anopheles gambiae s.s. Annals of Tropical Medicine & Parasitology. 94(4):389-398.
Wetzel et al. (2001). Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system. Proc. Natl. Acad. Sci. USA. 98(16):9377-9380.
Bentrop, et al.;An arrestin homolog of blowfly photoreceptors stimulates visual-pigment phosphorylation by activating a membrane-associated protein kinase; Eur. J. Biochem (1993) 216: 67-73.
Boekhoff, et al.;Termination of second messenger signaling in olfaction; Proc. Natl. Acad. Sci.; Jan. 1992; 89: 471-474.
Clyne, et al.;A Novel Family of Divergent Seven-Transmembrane Proteins: Candidate Odorant Receptors in Drosophila; Neuron, Feb. 1999; vol. 22, 327-338.
Fox, et al.;Candidate Odorant Receptors from the Malaria Vector Mosquito, Anopheles Gambiae AND evidence of Down-Regulation in Response to Blood Feeding; PNAS, vol. 98, No. 25, Dec. 2001, 14693-14697.
Hyde, et al.;Twenty Drosophila visual system cDNA clones: One is a homolog of human arrestin; Proc. Natl. Acad. Sci.; Feb. 1990; 87: 1008-1012.
Levine III, et al.;Isolation of a Novel Visual-System-Specific Arrestin: AnIn VivoSubstrate for light-Dependent Phosphorylation., Mechanisms of Development, Dec. 1990, 1:19-25.
Merrill, et al.;Visual Arrestins in Olfactory Pathways of Drosophila and the Malaria Vector Mosquito Anopheles Gambiae; PNAS, vol. 99, No. 3; Feb. 5, 2002; 1633-1638.
Raming, et al.;Arrestin-Subtypes in Insect Antennae; Cellular Signaling; 1993; 5: 69-80.
Roman, et al.; Kurtz,a Novel Nonvisual Arrestin, Is an Essential Neural Gene in Drosophila; Genetics; Jul. 2000; 155: 1281-1295.
Smith, et al.;Isolation and structure of an arrestin gene from Drosophila; Proc. Natl. Acad. Sci; Feb. 1990; 87: 1003-1007.
Smith, et al.;Isolation and expression of an arrestin cDNA from the horseshoe crab lateral eye; Journal of Neurochemistry; 1995; 64; 1-12.
Vosshall;The Molecular Logic of Olfaction in Drosophila; Chem. Senses (2001) 26: 207-213.
Vosshall, et al.;A Spatial Map of Olfactory Receptor Expression in the Drosophila Antenna; Cell, vol. 96; Mar. 5, 1999; 725-736.
Yamada, et al.;A 49-Kilodalton Phosphoprotein in the Drosophila Photoreceptor is an Arrestin Homolog; Science, vol. 248 (Apr. 27, 1990); 483-486.
Vosshall, et al.; International Publication No. WO 00/50566; International Application No. PCT/US00/04995; International; Publication Date: Aug. 31, 2000; International Filing Date: Feb. 25, 2000; Title:Genes Encoding Insect Odorant Receptors and Uses Thereof; International Patent Classification: C12N; Published by the World Intellectual Property Organization, International Bureau.
Nighorn, et al.;Dissecting the Molecular Mechanisms of Olfaction in a Malaria-Vector Mosquito; PNAS, vol. 99, No. 3; Feb. 5, 2002; 1113-1114.
Dobritsa, et al.;Integrating the Molecular and Cellular Basis of Odor Coding in the Drosophila Antenna; Neuron, Mar. 6, 2003, 37: 827-841.
Hill, et al.;G Protein-Coupled Receptors in Anopheles gambiae; Science, vol. 298 (Oct. 4, 2002); 176-178, and 58 page on-line supplement.
Wetzel, et al.;Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system, PNAS (Jul. 31, 2001) 98:9377-9380.
Hallem, et al.;Mosquito Receptor for Human-Sweat Odorant; Nature (Jan. 15, 2004) 427:212-213. (not considered to be prior art by the applicant).
Fox, et al.;A Cluster of Candidate Odorant Receptors from the Malaria Vector Mosquito, Anopheles gambiae; Chem. Senses (2002) 27:453-459.
Wetzel, et al.;Specificity and Sensitivity of a Human Olfactory Receptor Functionally Expressed in Human Embryonic Kidney 293 Cells and Xenopus Laevis Oocytes; Journal of Neuroscience (Sep. 1, 1999) 19(17):7426-7433.
Pitts, et al.;A Highly Conserved Candidate Chemoreceptor Expressed in both olfactory and gustatory tissues in the malaria vector Anopheles gambiae; PNAS (Apr. 6, 2004) 101:5058-5063. (not considered to be prior art by the applicant).
Hallem et al.;The Molecular Basis of Odor Coding in the Drosophila Antenna; Cell (Jun. 25, 2004) 117:965-979. (not considered to be prior art by the applicant).
Pierce et al. (2001). Classical and new roles of B-arrestins in the regulation of G-protein-coupled receptors. Nature Reviews. 2:727-733.
Fukuto et al. (2004). G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Neuron 42:581-593.
Dolph, P.J. (2002). Arrestin: roles in the life and death of retinal neurons. The Neuroscientist 8(4):347-355.
McDonald et al. (2000). B-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science 290:1574-1577.
Gurevich et al. (1995). Visual arrestin binding to rhodopsin. The Journal of Biological Chemistry. 270(11):6010-6016.
Wells, J.A. (1990). Additivity of mutational effects in proteins. Biochemistry. 29(37):8509-8517.
Ngo et al. (1994). Computational complexity, protein structure prediction, and the Levinthal paradox. In Merz and Le Grand (Eds.) The Protein Folding Problem and Tertiary Structure Prediction. Birkhauser:Boston, pp. 492-495.
Fukuto et al. G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Neuron. May 2004, vol. 42. No. 4, pp. 581-593.
Merril et al. Visual aarrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae. Proc. Natl. Acad. Sci. USA. Feb. 2002, vol. 99, No. 3, pp. 1633-1638.
Merril et al. Molecular characterization of arrestin family members in the malaria vector mosquito, Anoopheles gambaie. Insect Molecular Biology, Dec. 2003, vol. 12, No. 6, pp. 641-650.
Xu et al. Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae. Insect Molecular Biology. Dec. 2003, vol. 12, No. 6, pp. 549-560.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of identifying chemical agents which stimulate... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of identifying chemical agents which stimulate..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying chemical agents which stimulate... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2755609

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.