Method of identifying cellular types in a biological sample supp

Details Method of identifying cellular types in a biological sample supp Method of identifying cellular types in a biological sample supp

1997-07-30

1999-08-31

Hannaher, Constantine

Radiant energy

Invisible radiant energy responsive electric signalling

Infrared responsive

2503418, G01N 2135

Patent

active

059456744

ABSTRACT:
A method of detecting cellular types in a biological sample supported on an infrared absorptive substrate, such as a plain glass slide, analyzes infrared light reflected from the sample using an Attenuated Total Reflection (ATR) technique. An infrared beam is directed to the sample through an ATR microscope objective. The depth of penetration of the infrared beam in the sample is controlled to avoid infrared spectral response from the absorptive substrate. The attenuated total reflection from the sample is detected and analyzed to determine the cellular types or the presence of anomalies in the sample. The method allows infrared measurements on cell samples mounted on plain glass slides, as are normally used by pathologists and other medical investigators.

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"Multivariate Classification of the Infrared Spectra of Cell and Tissue Samples" by David M. Haaland, Howland D. T. Jones, and Edward V. Thomas--Applied Spectroscopy, vol. 51, No. 3, 1997, pp. 340-345.

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