Method of identifying and modulating the activity of label retai

Details Method of identifying and modulating the activity of label retai Method of identifying and modulating the activity of label retai

1992-11-04

1994-01-18

Housel, James C.

Chemistry: analytical and immunological testing

Biological cellular material tested

435 29, 424 2, G01N 3348

Patent

active

052799697

ABSTRACT:
Methods of detecting label retaining cells in self-renewing tissues, such as hair follicle, are provided. Methods of modulating the activity of slow-cycling cells and methods of evaluating the efficacy of agents for modulating the activity of stem cell populations are also provided. Generally, cells are continuously labeled, induced into a proliferative phase by exposure to an agent such as TPA or a cytokine, and then observed in relation to established criteria.

REFERENCES:
patent: 4806476 (1989-02-01), Coons et al.
Cotsarelis et al., J. Invest. Dermol., 92(3) (1989a).
Cotsarelis et al., Cell 57:201-209 (1989b).
Cotsarelis et al., Cell 61:1329-1337 (1990).

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