Method of identifying and modulating the activity of label retai

Details Method of identifying and modulating the activity of label retai Method of identifying and modulating the activity of label retai

1993-10-12

1994-08-23

Housel, James C.

Chemistry: analytical and immunological testing

Biological cellular material tested

435 29, 424 2, G01N 3348

Patent

active

053407440

ABSTRACT:
Methods of detecting label retaining cells in self-renewing tissues, such as hair follicle, are provided. Methods of modulating the activity of slow-cycling cells and methods of evaluating the efficacy of agents for modulating the activity of stem cell populations are also provided. Generally, cells are continuously labeled, induced into a proliferative phase by exposure to an agent such as TPA or a cytokine, and then observed in relation to established criteria.

REFERENCES:
patent: 4806476 (1989-02-01), Coons et al.
patent: 5229271 (1993-07-01), Philpott
Cotsarelis et al., An Improved Method for Detection of Epithelial Stem Cells, J. Invest. Dermol., 92(3), 1989a.
Cotsarelis et al., Existence of Slow-Cycling Limbal Epithelial Basal Cells That Can be Preferentially Stimulated to Proliferate: Implications on Epithelial Stem Cells, Cell, 57:201-209 1989b.
Cotsarelis et al., Label-Retaining Cells Reside in the Bulge Area of Pilosebaceous Unit: Implications for Follicular Stem Cells, Hair Cycle, and Skin Carcinogenesis, Cell, 61:1329-1337 1990.

Affiliated with

Also associated with

Rating

Method of identifying and modulating the activity of label retai does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of identifying and modulating the activity of label retai, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying and modulating the activity of label retai will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-502420