Method of identifying agonists and antagonist for CC-CKR5 recept

Details Method of identifying agonists and antagonist for CC-CKR5 recept Method of identifying agonists and antagonist for CC-CKR5 recept

1997-07-11

1999-07-27

Ulm, John

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 6, 435 71, 435 72, 436501, C12Q 168, G01N 3353, G01N 33566

Patent

active

059288817

ABSTRACT:
The invention provides a method of screening compounds to identify those which enhance or block the action of CC-CKR5. Further provided are compounds which blcok (antagonists) or enhance (agonists) the action of CC-CKR5.

REFERENCES:
Combadiere et al., "Cloning and functional expression of a human eosimophil CC chemokine receptor", The Journal of Biological Chemistry, 270, pp. 16491-16494 (Dec. 15, 1995).
Carol J. Raport, J. Gosling, Vicki L. Schweickart, Patrick W. Gray, and Isreal F. Charo; Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1.beta., MIP-1.alpha.*; Journal of Biological Chemistry; vol. 271, No. 29, Jul. 19, 1996; pp. 17161-17166.
Ghalib Alkhatib, Christophe Combadiere, C.C. Broder, Yu Feng, P.E. Kennedy, P.M. Murphy and E.A. Berger; CC CKR5; A RANTES, MIP-1.alpha., MIP-1.beta. Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1; Science; vol. 272; Jun. 28, 1996; pp. 1955-1958.
Michael Samson, Olivier Labbe, Catherine Mollereau, Gilbert Vassart and Marc Parmentier; Molecular Cloning and Functional Expression of a New Human CC-Chemokine Receptor Gene; Biochemistry; vol. 35, No. 11, 1996; pp. 3362-3367.
Christophe Combadiere, Sunil K. Ahuja and Philip M. Murphy; Cloning and Functional Expression of a Human Eosinophil CC Chemokine Receptor; Jouranl of Biological Chemistry; vol. 270, No. 27, Jul. 14, 1995; pp. 16491-16494.
David N. Leff; Second HIV Cofactor Discovery In Six Weeks Advances Basis For Drug Development; Bioworld Today-The Daily Biotechnology Newspaper; vol. 7, No. 122; Jun. 21, 1996.

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