Method of identifying agents which modulate ICAM-3 binding to LF

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 72, G01N 3353

Patent

active

056291620

ABSTRACT:
The present invention relates to intercellular adhesion molecules (ICAM-3) which is involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes therapeutic and diagnostic uses for adhesion molecules and for the antibodies that are capable of binding them.

REFERENCES:
Anderson, D.C. et al., Leukocyte LFA-1, OKM1, p150,95 deficiency syndrome: functional and biosynthetic studies of three kindreds, Fed. Proceedings 44(10):2671-2677 (Jul. 1985).
Anderson, D.C. et al., The Severe and Moderate Phenotypes of Heritable Mac-1, LFA-1 Deficiency: Their Quantitative Definition and Relation to Leukocyte Dysfunction and Clinical Features, J. Infect. Dis. 152(4):668-689 (Oct. 1985).
Bagnasco, M. et al., Functional Involvement of the LFA-1/ICAM-1 Adhesion System in the Autologous Mixed Lymphocyte Reaction, Cell. Immunol. 128:362-369 (1990).
Barnes, P.J. et al., The effect of airway epithelium on smooth muscle contractility in bovine trachea, Br. J. Pharmac. 86:685-691 (1985).
Campanero, M.R. et al., ICAM-3 Interacts with LFA-1 and Regulates the LFA-1/ICAM-1 Cell Adhesion Pathway, J. Cell Biol. 123(4):1007-1016 (Nov. 1993).
Christiansen, S.C. et al., Detection of Tissue Kallikrein in the Bronchoalveolar Lavage Fluid of Asthmatic Subjects, J. Clin. Invest. 79:188-197 (Jan. 1987).
Cosimi, A.B. et al., In Vivo Effects Of Monoclonal Antibody To ICAM-1 (CD54) In Nonhuman Primates With Renal Allografts, J. Immunol. 144(12):4604-4612 (Jun. 15, 1990).
Davignon, D. et al., Lymphocyte function-associated antigen 1, (LFA-1): A surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing, Proc. Natl. Acad. Sci. USA 78(7):4535-4539 (Jul. 1981).
de Fougerolles, A.R. et al., Intercellular Adhesion Molecule 3, a Third Adhesion Counter-Receptor for Lymphocyte Function-associated Molecule 1 on Resting Lymphocytes, J. Exp. Med. 175:185-190 (Jan. 1992).
Dransfield, I. et al., Early Events of the Immune Response Mediated by Leukocyte Integrins, Immunol. Rev. 114:29-44 (1990).
Dustin, M.L. et al., T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1, Nature 341:619-624 (Oct. 19, 1989).
Eisen, H.W., The Cellular Basis For Immune Responses, in Microbiology, 3rd ed., Harper & Row, Philadelphia, PA, pp. 381-418 (1980).
Eisen, H.W., The Origins of Immunology, in Microbiology, 3rd ed., Harper & Row, Philadelphia, PA, pp. 290-295 (1980).
Flavahan, N.A. et al., Respiratory epithelium inhibits bronchial smooth muscle tone, J. Appl. Physiol. 58:834-838 (1985).
Flavin, T. et al., Monoclonal Antibodies Against Intercellular Adhesion Molecule 1 Prolong Cardia Allograft Survival in Cynomolgus Monkeys, Transplant. Proceedings 23(1):533-534 (Feb. 1991).
Frigas, E. et al., The eosinophil and the pathophysiology of asthma, J. Allergy Clin. Immunol. 77(4):527-537 (Apr. 1986).
Gartner, S. et al., The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection, Science 233:215-219 (Jul. 11, 1986).
Godard, P. et al., Functional assessment of alveolar macrophages: comparison of cells from asthmatics and normal subjects, J. Allergy Clin. Immunol. 70(2):88-93 (Aug. 1982).
Hildreth, J.E.K. et al., Involvement of a Leukocyte Adhesion Receptor (LFA-1) in HIV-Induced Syncytium Formation, Science 244:1075-1078 (Jun. 2, 1989).
Johnson, R.T. et al., The neurobiology of human immunodeficiency virus infections, FASEB J. 2:2970-2981 (Nov. 1988).
Juan, M. et al., CDw50 and ICAM-3: Two names for the same molecule, Eur. J. Immunol. 23:1508-1512 (1993).
Keizer, G.D. et al., Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA-1, Mo-1 and p150,95, Eur. J. Immunol. 15:1142-1147 (1985).
Makgoba, M.W. et al., Functional evidence that intercellular adhesion molecule-1 (ICAM-1) is a ligand for LFA-1-dependent adhesion in T cell-mediated cytotoxicity, Eur. J. Immunol. 18:637-640 (1988).
Makgoba, M.W. et al., The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition, Immunol. Today 10:417-422 (1989).
Marlin, S.D. et al., Purified Intercellular Adhesion Molecule-1 (ICAM-1) Is a Ligand for Lymphocyte Function-Associated Antigen 1 (LFA-1), Cell 51:813-819 (Dec. 4, 1987).
Rossen, R.D. et al., HIV-1-Stimulated Expression Of CD11/CD18 Integrins And ICAM-1: A Possible Mechanism For Extravascular Dissemination Of HIV-1-Infected Cells, Trans. Assoc. Amer. Physicians 102:117-130 (1989).
Sanchez-Madrid, F. et al., A Human Leukocyte Differentiation Antigen Family With Distinct .alpha.-Subunits And A Common .beta.-Subunit, J. Exp. Med. 158:1785-1803 (Dec. 1983).
Schnittman, S.M. et al., Characterization Of GP120 Binding To CD4 And An Assay That Measures Ability Of Sera To Inhibit This Binding, J. Immunol. 141(12):4181-4186 (Dec. 15, 1988).
Seed, B. et al., Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure, Proc. Natl. Acad. Sci. USA 84:3365-3369 (May 1987).
Springer, T. et al., MAC-1: a macrophage differentiation antigen identified by a monoclonal antibody, Eur. J. Immunol. 9:301-306 (1979).
Springer, T.A. et al., LFA-1 and Lyt-2,3, Molecules Associated with T Lymphocyte-Mediated Killing; and Mac-1, an LFA-1 Homologue Associated with Complement Receptor Function, Immunol. Rev. 68:171-195 (1982).
Springer, T.A., The LFA-1, Mac-1 glycoprotein family and its deficiency in an inherited disease, Fed. Proceedings 44(10):2660-2663 (Jul. 1985).
Stoler, M.H. et al., Human T-Cell Lymphotropic Virus Type III Infection of the Central Nervous System, J. Amer. Med. Assoc. 256(17):2360-2364 (Nov. 7, 1986).
Valentin, A. et al., The Leukocyte Adhesion Glycoprotein CD18 Participates In HIV-1-Induced Syncytia Formation In Monocytoid And T Cells, J. Immunol. 144(3):934-937 (Feb. 1, 1990).
Hadam, M. R., "N11 Cluster report: CDw50," 667-670 (1989).
Vilella, R. et al., "Involvement of the CDw50 molecule in allorecognition," Tissue Antigens 36:203-210 (Nov. 1990).
Knapp et al. 1989 4th Int'l Workshop & Conference hu LDA.
de Fougerolles et al 1991 J Exp. Med 174:253-267.
Fawcett et al 1992 Nature 360:481.
Vazeux et al 1992 Nature 360:485.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of identifying agents which modulate ICAM-3 binding to LF does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of identifying agents which modulate ICAM-3 binding to LF, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying agents which modulate ICAM-3 binding to LF will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1384404

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.