Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-07-06
2008-08-05
Spector, Lorraine (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C435S007100, C530S350000
Reexamination Certificate
active
07407769
ABSTRACT:
Taste receptor polycystin-2L1 is provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals, methods of detecting polymorphisms, and methods of correcting taste defects are also provided.
REFERENCES:
patent: 2002/0037515 (2002-03-01), Margolskee et al.
patent: 2002/0127623 (2002-09-01), Minshull et al.
patent: WO 00/44929 (2000-08-01), None
patent: WO 00/45179 (2000-08-01), None
patent: WO 00/45179 (2000-08-01), None
patent: WO 03/025137 (2003-03-01), None
Chen et al., Polycystin-L is a calcium regulated cation channel permeable to calcium ions. Nature, 401, 383-385, 1999.
Alexander et al. (1992) “Altering the antigenicity of proteins”Proc. Natl. Acad. Sci. USA89: 3352-3356.
Avenet & Lindemann (1989) “Perspectives in taste reception”J Membr Biol.112, 1-8.
Basora et al. (2002) “Tissue and Cellular Localization of a Novel Polycystic Kidney Disease-Like Gene Product, Polycystin-L”J. Am. Soc. Nephrol13:293-301.
Bernhardt et al. (1996) “Changes in IP3and cytosolica CA2+in response to sugards and non-sugar sweeteners in transduction of sweet tast in the rat”J. Physiol490:325-336.
Bowie et al. (1990) “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions”Science247:1306-1310.
Doolin et al. (1996) “Distribution and Characterization of Functional Amiloride-sensitive Sodium Channels in Rat Tongue”J. Gen. Physiol. 107: 545-554.
Gilbertson et al., “The molecular physiology of taste transduction”Curr. Opin. Neurobiol. 10; 519-527, 2000.
Hoon et al. (1999) “Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity”Cell96:541-51.
Kinnamon et al., (1992) “Chemosensory transduction mechanisms in taste”Annu. Rev. Physiol. 54:715-731.
Lin and Corey (2005) “TRP channels in mechanosensation”Curr Opin Neurobiol. 15(3):350-7.
Lindemann (1996) “Taste reception”Physiol. Rev. 76:718-766.
Liu et al. (2003) “Intracellular Ca2+and the phospholipids PIP2regulate the taster transduction ion channel TRPM5”Proc. Natl. Acad. Sci.USA 100(25): 15160-15165.
Madden et al. (1997) “Taste Perception in Cirrhosis: Its Relationship to Circulating Micronutrients and Food Preferences”Hepatology26(1): 40-48.
Margolskee (1993) “The molecular biology of taste transduction”R. Bioessays15, 645-650.
Mueller et al. (2005) “The receptors and coding logic for bitter taste”Nature434 (7030): 225-9.
Nauli and Zhou 2004 “Polycystins and Mechanosensation in renal and nodal cilia”Bioessays26.8 844-856.
Nelson et al. (2001) “Mammalian sweet taste receptors”Cell106(3): 381-90.
Nelson et al. (2002) “An amino-acid taste receptor”Nature416(6877): 199-202.
Nomura, et al. (1998) “Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects”J. Biol. Chem. 273:25967-25973.
Ogura et al. (1997) “Bitter Taste Transduction of Denatonium in the Mudpuppy Necturus Maculosus,”J. of Neuroscience, 17(10): 3580-3587.
Roper et al. (1989) “Distribution of Ion Channels on Taste Cells and Its Relations to Chemosensory Transduction,”J. Membrane Biology109(1):29-39.
Roper (1989) “The cell biology of vertebrate taste receptors”Ann. Rev. Neurosci. 12:329-353.
Wu et al. (1998) “Identification of PKD2L, a Human PKD2-Related Gene: Tissue-specific Expression and Mapping to Chromosome 10q25”Genomics54(3) 564-568.
Zhang et al. (2003) “Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”Cell112(3):293-301.
Zhao et al. (2003) “The receptors for mammalian sweet and umami taste”Cell115(3):255-66.
Huang Angela L.
Zuker Charles
Quine Jonathan Alan
Quine Intellectual Property Law Group P.C.
Spector Lorraine
Stoica Elly-Gerald
The Regents of the University of California
LandOfFree
Method of identifying activity modulators of a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of identifying activity modulators of a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying activity modulators of a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4004846