Method of identifying a potential substrates of an...

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C702S019000, C703S011000, C435S015000

Reexamination Certificate

active

07966133

ABSTRACT:
The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyl-transferases, methods of identifying potential substrates of O-methyltransferases, and methods of identifying potential inhibitors of methyltransferases.

REFERENCES:
patent: 5503975 (1996-04-01), Smith et al.
patent: 6184211 (2001-02-01), Szyf
patent: 6232108 (2001-05-01), Philips
patent: 2007/0020684 (2007-01-01), Bledsoe et al.
patent: WO 01/07579 (2001-02-01), None
patent: WO 02/18604 (2002-03-01), None
Flower, “Drug Design, Cutting Edge Approaches,” Royal Society of Chemistry, Cambridge, UK, 2002, pp. 21-27.
Decker et al., “Nucleotide Sequences and heterologous expression oftcmGandtcmP, biosynthetic genes for tetracenomycin C inStreptomyces glaucescens.” Journal of Bacteriology, 175:3876-3886, Jun. 1993.
Noel and Tsai, “Phospholipase A2engineering: design, synthesis and expression of a gene for bovine (Pro)Phospholipase A2.” Journal of Cellular Biochemistry, 40:309-320, 1989.
Redlak et al., “Interaction of tRNA with tRNA (Guanosine-1)methyltransferase: Binding specificity determinants involve the dinucleotide G36pG37and tertiary structure.” Biochemistry, 36:8699-8709, 1997.
Skinner et al., “Crystal structure of protein isoaspartyl methyltransferase: A catalyst for protein repair.” Structure, 8:1189-1201, 2000.
Vidgren et al., “Crystal structure of catechol O-methyltransferase.” Nature, 368: 354-358, 1994.
Intemational Search Report for international application PCT/US01/47852, Dec. 10, 2002.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of identifying a potential substrates of an... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of identifying a potential substrates of an..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying a potential substrates of an... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2707707

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.