Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-03-01
2005-03-01
McKelvey, Terry (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S456000, C435S471000, C435S455000
Reexamination Certificate
active
06861229
ABSTRACT:
The present invention provides a method of identifying a gene product. The method comprises providing a multiplicity of cells comprising a first gene product. Preferably, the first gene product is produced in the multiplicity of cells by expressing a first exogenous nucleic acid sequence encoding the first gene product. A library of second nucleic acid sequences encoding second gene products is then introduced into the multiplicity of cells. The second nucleic acid sequences are expressed in the multiplicity of cells to produce the second gene products such that the first gene product and at least one of the second gene products contact. The method further comprises causing a complex to form between the first gene product, an affinity molecule that binds the first gene product, and at least one of the second gene products, and subsequently retrieving the complex. At least one second gene product of the complex then is identified.
REFERENCES:
patent: 5174962 (1992-12-01), Brennan
patent: 5493115 (1996-02-01), Deinzer et al.
patent: 5538897 (1996-07-01), Yates et al.
patent: 5605798 (1997-02-01), Köster
patent: 5719060 (1998-02-01), Hutchens et al.
patent: 5723031 (1998-03-01), Dürr et al.
patent: 5939250 (1999-08-01), Short
patent: 5965358 (1999-10-01), Carrión et al.
patent: 6114111 (2000-09-01), Luo et al.
patent: WO 9719110 (1997-05-01), None
patent: WO 9720918 (1997-06-01), None
patent: WO 9743301 (1997-11-01), None
patent: WO 9928745 (1999-06-01), None
patent: WO 9936516 (1999-07-01), None
patent: WO 0023564 (2000-04-01), None
patent: WO 0111087 (2001-02-01), None
Tanahashi et al., Biochem. Biophys. Res. Comm 255, pp. 663-667 (1999).*
Dey et al., J. Biol. Chem., vol. 273, No. 37, pp. 24095-24101 (1998).*
Zambrano et al., J. Biol. Chem., vol. 273, No. 32, pp. 20128-20133 (1998).*
Elangovan et al., J. Biol. Chem., vol. 272, No. 39 pp. 24494-24498, (1987).*
Germino et al., Proc. Natl. Acad. Sci., 90, pp. 933-937 (1993).*
Berkner , Curr. Top. Microbiol. and Immunol., 158, pp. 39-66 (1992).*
ANONYMOUS, “Probing Viruses with Mass Spec,”R&D Magazine, p. 33 (Jun., 1998).
Blackstock et al.,Tibtech, 17, 121-127 (1999).
Bothner et al.,J. Biol. Chem., 273, 673-76 (1997).
Bothner et al.,Nature Structural Biology, 6(2), 114-116 (1999).
Corman et al.,Biomedical and Environmental Mass Spectrometry, 19, 646-654 (1990).
Davison et al.,Virology, 206, 1035-1043 (1995).
Despeyroux et al.,Rapid Communications in Mass Spectrom., 10, 937-41 (1996).
Fenselau,Ann. Rev. Biophys. Biophys. Chem., 20, 205-220 (1991).
Fetzer et al.,Protein Expression and Purification, 5, 432-441 (1994).
Glocker et al.,Biochemistry, 35, 14625-14633 (1996).
Gross et al.,Spectrom. Online, (May 28, 1998).
Hillenkamp et al.,Anal. Chem., 63(24), 1193A-1203A (Dec. 15, 1991).
Hillenkamp et al.,Biological Mass Spectrom., Proceedings of the Second International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco, CA, Aug. 27-31, 1989, 49-60 (1990).
Jurinke et al.,Genetic Analysis: Biomolecular Engineering, 13, 67-71 (1996).
Koenigs et al.,Biochemistry, 38, 2312-2319 (1999).
Lamond et al.,Trends in Cell Biol., 7, 139-142 (Apr. 1997).
Link et al.,Nat. Biotechnol., 17, 676-682 (Jul. 1999).
Maizel et al.,Virology, 36, 126-136 (1968).
Mann et al.,Anal. Chem., 66(24), 4390-4399 (1994).
Marmey et al.,Virology, 253, 319-325 (1999).
McCormack et al.,Anal. Chem., 69, 767-776 (Feb. 1997).
Nakanishi et al.,Biological Mass Spectrometry, 23, 230-233 (1994).
Owens et al.,Bioorg. Med. Chem., 6, 1547-1554 (1998).
Pepinsksy et al.,J. Virol., 70, 3313-18 (1996).
Roepstorff,Curr. Opin. Biotechnol., 8, 6-13 (1997).
Romano et al.,Mol. Cell. Biol., 18(2), 2282-2297 (1998).
Salmon et al.,Protein Expression and Purification, 9, 203-210 (1997).
Schriemer et al.,Anal. Chem., 70(8), 1569-1575 (1998).
Siuzdak et al.,Chemistry&Biology, 3(1), 45-48 (1996).
Siudzak,J. Mass Spectrom., 33, 203-211 (1998).
Sönksen et al.,Anat. Chem., 70, 2731-2736 (Jul. 1998).
Streckert et al.,Intervirology, 36, 128-133 (1993).
Summerford et al.,Nature Med., 5(5), 587-588 (1999).
Taranenko et al.,Nucl. Acids Res., 26(10), 2488-2490 (1998).
Tas et al.,Biomedical and Environmental Mass Spectrometry, 18, 757-760 (1989).
Thomas et al.,Anal. Chem., 70(18), 3863-3867 (1998).
Tissue, “Mass Spectrometry Ionization Methods,”Scimedia(Nov. 3, 1996).
Uyeda et al.,The Journal of Antibiotics, 51(9), 823-828 (1998).
van der Greef et al.,Biomedical and Environmental Mass Spectrometry, 16, 45-50 (1988).
Vastola et al.,Organic Mass Spectrometry, 3, 101-104 (1969).
Yates,Trends in Genet., 16(1), 5-8 (Jan. 2000).
Yu et al.,J. Am. Soc. Mass Spectrom., 9, 208-215 (1998).
Crystal,Science, 270, 404-410 (1995).
Sewalt et al.,Mol. Cell. Biol., 19 (1), 777-787 (Jan. 1, 1999).
Carrión Miguel E.
Kovesdi Imre
GenVec, Inc.
McKelvey Terry
Vogel Nancy T.
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