Method of identification of compounds effective against...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of storing cells in a viable state

Reexamination Certificate

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C435S375000, C435S377000, C435S395000

Reexamination Certificate

active

07575926

ABSTRACT:
A method for identifying compounds capable of targeting suppressed cancer cells, the method including the steps of comparing the response to a test compound of cancer cells grown on a suppressing cell support matrix which causes suppression of a malignant phenotype in a growing cancer cell and on a non-suppressing cell support matrix.

REFERENCES:
patent: 2006/0074041 (2006-04-01), Johnston et al.
patent: WO 00/06088 (2000-02-01), None
patent: WO0240717 (2002-05-01), None
patent: WO2005107743 (2005-11-01), None
Abstract if Clarkson et al (Cancer, 1965, vol. 18, pp. 1189-1213).
Abstract of Miller et al (Clin Exp Metastasis, 1998, vol. 16, pp. 480-486).
Danson et al, Cancer chemother Pharmacol, 2007, vol. 10, pp. 851-861).
Hurst, R., et al., “Matrix-dependent Plasticity of the Malignant Phenotype of Bladder Cancer Cells”,Anticancer Research23: 3119-3128; 2003.
Kyker, K., et al., “A Model for 3-dimensional growth of bladder cancers to investigate cell-matrix interaction”,Urologic Oncology: Seminars and Orginal Investigation 21: 255-261, 2003.
Hurst, R., et al., “A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SIS gel”,Science Direct CancerLetters 217: 171-180, 2005.

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