Method of hydroxylation with ATCC 55086

Details Method of hydroxylation with ATCC 55086 Method of hydroxylation with ATCC 55086

1992-02-20

1993-02-16

Cashion, Jr., Merrell C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

4352535, 435 681, C12P 100, C12N 120

Patent

active

051870746

ABSTRACT:
A novel dipeptide isostere is the biotransformed product after incubation with a culture of Streptomyces. It inhibits HIV protease, and is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a compound, pharmaceutically acceptable salt, pharmaceutical composition ingredient, whether or not as a prodrug or as a combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

REFERENCES:
patent: 4661473 (1987-04-01), Boger et al.
patent: 4965200 (1990-10-01), Chen et al.
patent: 4980283 (1989-06-01), Huang
patent: 4996149 (1991-02-01), Jarreau et al.
Evans, B. E. et al., "A Stereocontolled Synthesis . . . ," Proc. Am. Pept. Symp., 9, 743 (1985) (Evans II).
Luly, J. R. et al., "A Synthesis of Protected Aminoalkyl Epoxides," J. Org. Chem. 52, 1487 (1987).
ASM News, vol. 56, No. 7 (Jul. 1990) at 368.
Power, M. D. et al., "Nucleotide Sequence of SRV-1 . . . ," Science 231, 1567 (1986).
Pearl, L. H. et al., "A Structural model for the retroviral proteases," Nature 329, 351 (1987).
Evans, B. E. et al., "A Stereocontrolled Synthesis . . . ," J. Org. Chem. 50, 4615 (1985) (Evans I).
Crawford, S. et al., "A Deletion Mutant in . . . pol . . . Blocks Proteolytic Processing . . . ," J. Virol. 53, 899 (1985).
Ratner, L. et al., "Complete Nucleotide Sequence of AIDS virus, HTLV-III," Nature 313, 277 (1985).
Toh, H. et al., "Close Structural Resemblance . . . ," EMBO J 4, 1267 (1985).
Ser. No. 07/452,912, filed Dec. 18, 1989.
Ser. No. 07/595,895, Oct. 11, 1990, Treiber (Merck 18206).
Ser. No. 07/595,909, Oct. 11, 1990, Balani (Merck 18207).
Ser. No. 07/595,894, Oct. 11, 1990, Chen (Merck 18208).

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