Method of hydroxylating 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-m

Details Method of hydroxylating 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-m Method of hydroxylating 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-m

1992-03-16

1993-04-13

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435189, C12P 1716

Patent

active

052022439

ABSTRACT:
Incubation of 3-[2-benzoxazol-2-yl)ethyl]-5-ethyl-6-methyl-2-(1H)-pyridinone ##STR1## with a preparation from mammalian organ yields as biotransformation product the 6-hydroxymethyl analog. This product is useful in the prevention or treatment of infection by HIV and the treatment of AIDS.

REFERENCES:
Ratner, L. et al., "Complete nucleotide sequence of the AIDS virus", HTLV-III, Nature 313, 277 (1985).
Toh, H. et al., "Close structural resemblance . . . ," EMO Journal 4, 1267 (1985).
Power, M. D. et al., "Nucleotide Sequence of SRV-1," Science 231, 1567 (1986).
Pearl, L. H. et al., "A structural model for Retroviral Proteases," Nature 329, 351 (1987).
Paine, J. B., "A Convenient Synthesis of Nicotinate Esters . . . , " J. Heterocyclic Chem. 24, 351 (1987).
Azri, S. et al., "Precision-Cut Liver Slices," In Vitro Toxicology 3, 309 (1990).
Smith, P. F. et al., "Dynamic Organ Culture of Precision Liver Slices . . . ," Liver Slices for In Viro Technology 36, 1367 (1985).
Krumdieck, C. L. et al., "A New Instrument for Rapid Preparation of Tissue Slices," Anal. Biochem. 104, 118 (1980).
Chapman, D. E. et al., "Metabolism and Covalent Binding of .sup.14 C-toluene by Human and Rat Liver Microsomal Fraction," Drug Metabolism and Disposition 18:929 (1990).

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