Method of hemodilution facilitated by monitoring oxygenation sta

Surgery – Blood drawn and replaced or treated and returned to body

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 5, A61K 4700

Patent

active

058657843

ABSTRACT:
A method for hemodiluting a patient is disclosed which includes the steps of administering a biocompatible oxygen carrier in conjunction with surgery or organ ischemia or infarct while assessing the patient's PvO.sub.2 or other oxygenation indices, and administering to the patient additional oxygen carrier or autologous blood in response to the PvO.sub.2 value if necessary to maintain the PvO.sub.2 at or above the desired level.

REFERENCES:
patent: 3975512 (1976-08-01), Long, Jr.
patent: 4073879 (1978-02-01), Long, Jr.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4473494 (1984-09-01), Tye
patent: 4526715 (1985-07-01), Kothe et al.
patent: 4600531 (1986-07-01), Walder
patent: 4698387 (1987-10-01), Schmidt et al.
patent: 4777244 (1988-10-01), Bonhard et al.
patent: 4861867 (1989-08-01), Estep
patent: 4911929 (1990-03-01), Farmer et al.
patent: 4987154 (1991-01-01), Long, Jr.
patent: 5344393 (1994-09-01), Roth et al.
patent: 5451205 (1995-09-01), Roth et al.
Faithfull, et al. "Peripheral Vascular Responses to Fluorocarbon Administration" Microvascular Research 33: 183-193 (1987).
Faithfull, et al. "Critical Levels of O.sub.2 Extraction Following Hemodilution with Dextran or Fluosol-DA" J. of Critical Care 3(1): 14-18 (1988).
Federspiel, et al. "A Theoretical Analysis of the Effect of the Particulate Nature of Blood on Oxygen Release in Capillaries" Microvascular Research 32: 164-189 (1986).
Gutierrez, G. "The Rate of Oxygen Release and Its Effect on Capillary O.sub.2 Tension: A Mathematical Analysis" Respiration Physiology 63: 79-96 (1986).
Homer, et al. "Oxygen Gradients Between Red Blood Cells in the Microcirculation" Microvascular Research 22:308-323 (1981).
Mebmer, et al. "Oxygen Supply to the Tissues During Limited Normovolemic Hemodilution" Res. Exp. Med. 159: 152-166 (1973).
Mercuriali, et al. Autologous Blood, pp. 2-30 Transmedica Europe Limited, Eastbourne, United Kingdom (1991).
Messmer, et al. "Present State of Intentional Hemodilution" Eur. Surg. Res. 18: 254-263 (1986).
NIH Consensus Conference "Perioperative Red Blood Cell Transfusion" JAMA 260(18): 2700-2703 (1988).
Riess, et al. "Reassessment of Criteria for the Selection of Perfluorochemicals for Second-Generation Blood Substitutes: Analysis of Structure/Property Relationships" Artificial Organs 8(1): 44-56 (1984).
Riess, et al. "Design, Synthesis and Evaluation of Fluorocarbons and Surfactants For In Vivo Applications: New Perfluoroalkylated Polyhydroxylated Surfactants" Int'l Symposium on Blood Substitutes, Montreal, (May, 1987) pp. 421-430.
Gould, et al. "Fluosol-DA As A Red-Cell Substitute in Acute Anemia" New England Journal of Medicine 314(26): 1653-1656 (1986).
Stehling, et al. "Acute Normovolemic Hemodilution" Transfusion 31(9): 857-868 (1991).
Weiskoff, R.B. "Mathematical Analysis of Isovolemic Hemodilution Indicates that It Can Decrease the Need for Allogeneic Blood Transfusion" Transfusion 35(1): 37-41 (1995).
Winslow, R. "A Model for Red Cell O.sub.2 Uptake" International J. of Clinical Monitoring and Computing 2:81-93 (1985).
Zauder, H. "Preoperative Hemoglobin Requirements" Anesthesiology Clinics of North America 8(3): 471-480 (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of hemodilution facilitated by monitoring oxygenation sta does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of hemodilution facilitated by monitoring oxygenation sta, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of hemodilution facilitated by monitoring oxygenation sta will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1112394

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.