Method of grinding pharmaceutical substances

Solid material comminution or disintegration – Processes – With application of fluid or lubricant material

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241 24, B02C 1716

Patent

active

058629998

ABSTRACT:
A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extremely fine particles, e.g., less than 100 nanometers in size, free of unacceptable contamination.

REFERENCES:
patent: 5320284 (1994-06-01), Nishida et al.

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