Method of generating metal chelating affinity ligands

Details Method of generating metal chelating affinity ligands Method of generating metal chelating affinity ligands

2006-02-28

2006-02-28

Therkorn, Ernest G. (Department: 1723)

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

C210S656000, C210S198200, C210S502100, C502S401000, C502S439000

Reexamination Certificate

active

07005071

ABSTRACT:
The present invention relates to a method of generating at least one polydentate metal chelating affinity ligand, which method comprises the steps ofa) providing at least one cyclic scaffold comprising a carbonyl, an adjacent sulphur and a nucleophile;b) providing at least one polydentate metal chelating affinity ligand arm, optionally in a form wherein the metal chelating functionalities are protected, on each scaffold by derivatisation of the nucleophile of said scaffolds, while retaining the cyclic structure of the scaffold;(c) ring-opening at the bond between the carbonyl and the sulphur of the derivatized scaffold by adding a reagent that adds one or more metal chelating affinity ligand arms to the scaffold; and, if required,(d) deprotecting the functionalities of the ligand arm(s) provided in step (b).In the most preferred embodiment of the method, steps (c) and (d) are performed simultaneously as one single step.

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